Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae

The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activation of iNKT in the context of Streptococcus pneumoni...

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Autores principales:	Shilpi Chandra, James Gray, William B. Kiosses, Archana Khurana, Kaori Hitomi, Catherine M. Crosby, Ashu Chawla, Zheng Fu, Meng Zhao, Natacha Veerapen, Stewart K. Richardson, Steven A. Porcelli, Gurdyal Besra, Amy R. Howell, Sonia Sharma, Bjoern Peters, Mitchell Kronenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dce5c3c771f4a1abdb502245e1a6bb5
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spelling	oai:doaj.org-article:4dce5c3c771f4a1abdb502245e1a6bb52021-12-02T17:31:28ZMrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae10.1038/s41467-018-06646-82041-1723https://doaj.org/article/4dce5c3c771f4a1abdb502245e1a6bb52018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06646-8https://doaj.org/toc/2041-1723The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activation of iNKT in the context of Streptococcus pneumoniae infection.Shilpi ChandraJames GrayWilliam B. KiossesArchana KhuranaKaori HitomiCatherine M. CrosbyAshu ChawlaZheng FuMeng ZhaoNatacha VeerapenStewart K. RichardsonSteven A. PorcelliGurdyal BesraAmy R. HowellSonia SharmaBjoern PetersMitchell KronenbergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shilpi Chandra James Gray William B. Kiosses Archana Khurana Kaori Hitomi Catherine M. Crosby Ashu Chawla Zheng Fu Meng Zhao Natacha Veerapen Stewart K. Richardson Steven A. Porcelli Gurdyal Besra Amy R. Howell Sonia Sharma Bjoern Peters Mitchell Kronenberg Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
description	The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activation of iNKT in the context of Streptococcus pneumoniae infection.
format	article
author	Shilpi Chandra James Gray William B. Kiosses Archana Khurana Kaori Hitomi Catherine M. Crosby Ashu Chawla Zheng Fu Meng Zhao Natacha Veerapen Stewart K. Richardson Steven A. Porcelli Gurdyal Besra Amy R. Howell Sonia Sharma Bjoern Peters Mitchell Kronenberg
author_facet	Shilpi Chandra James Gray William B. Kiosses Archana Khurana Kaori Hitomi Catherine M. Crosby Ashu Chawla Zheng Fu Meng Zhao Natacha Veerapen Stewart K. Richardson Steven A. Porcelli Gurdyal Besra Amy R. Howell Sonia Sharma Bjoern Peters Mitchell Kronenberg
author_sort	Shilpi Chandra
title	Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
title_short	Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
title_full	Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
title_fullStr	Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
title_full_unstemmed	Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
title_sort	mrp1 is involved in lipid presentation and inkt cell activation by streptococcus pneumoniae
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4dce5c3c771f4a1abdb502245e1a6bb5
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Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae

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