TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer

Lirong Zhu,1* Xiaodong Xu,2* Yijie Tang,3 Xiaochao Zhu41Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China; 2Department of General Surgery, Yancheng First People’s Hospital, Yancheng, Jiangsu, People’s...

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Autores principales:	Zhu L, Xu X, Tang Y, Zhu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Gastric cancer TRIP6 Prognosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4dd0270e51784fe48a1ca58cadd946b4
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spelling	oai:doaj.org-article:4dd0270e51784fe48a1ca58cadd946b42021-12-02T05:09:10ZTRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer1177-5491https://doaj.org/article/4dd0270e51784fe48a1ca58cadd946b42019-06-01T00:00:00Zhttps://www.dovepress.com/trip6-functions-as-a-potential-oncogene-and-facilitated-proliferation--peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Lirong Zhu,1* Xiaodong Xu,2* Yijie Tang,3 Xiaochao Zhu41Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China; 2Department of General Surgery, Yancheng First People’s Hospital, Yancheng, Jiangsu, People’s Republic of China; 3Department of Clinical Medicine, Medical College of Nantong University, Nantong, Jiangsu, People’s Republic of China; 4Department of General Surgery, Suqian First People’s Hospital, Suqian, Jiangsu, People’s Republic of China*These authors contributed equally to this work Background: Increasing evidence suggests that TRIP6 has been considered to be aberrantly regulated in several malignancies and involved in tumor growth and metastasis. However, the biological role and prognostic significance of TRIP6 in gastric cancer (GC) still remains unclear.Materials and methods: TRIP6 expression was determined in matched GC tissues and adjacent normal tissues by western blot and real-time PCR. Then, immunohistochemistry was used to detect the expression of TRIP6 in GC patients. Statistical analysis was performed to evaluate the correlation between TRIP6 expression and clinicopathological characteristics and prognosis. Moreover, the effects of TRIP6 on GC cell proliferation and migration were also investigated by using MTT, colony formation and transwell assays.Results: We observed that the expression of TRIP6 was significantly up-regulated in GC tissues and cell ines. Our data indicated that high TRIP6 expression exhibited a significant correlation with poor prognosis for GC patients. Multivariate analysis showed that TRIP6 expression was an independent prognostic factor of the overall survival of GC patients. Furthermore, ectopic expression of TRIP6 promotes cell proliferation and migration in BGC823 cells, whereas knockdown of TRIP6 suppresses cell proliferation and migration in MKN45 cells.Conclusion: These findings demonstrate that TRIP6 exerts an important role in cancer development, which represents a potential prognostic indicator in GC.Keywords: gastric cancer, TRIP6, prognosisZhu LXu XTang YZhu XDove Medical PressarticleGastric cancerTRIP6PrognosisMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 13, Pp 101-110 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gastric cancer TRIP6 Prognosis Medicine (General) R5-920
spellingShingle	Gastric cancer TRIP6 Prognosis Medicine (General) R5-920 Zhu L Xu X Tang Y Zhu X TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer
description	Lirong Zhu,1* Xiaodong Xu,2* Yijie Tang,3 Xiaochao Zhu41Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China; 2Department of General Surgery, Yancheng First People’s Hospital, Yancheng, Jiangsu, People’s Republic of China; 3Department of Clinical Medicine, Medical College of Nantong University, Nantong, Jiangsu, People’s Republic of China; 4Department of General Surgery, Suqian First People’s Hospital, Suqian, Jiangsu, People’s Republic of China*These authors contributed equally to this work Background: Increasing evidence suggests that TRIP6 has been considered to be aberrantly regulated in several malignancies and involved in tumor growth and metastasis. However, the biological role and prognostic significance of TRIP6 in gastric cancer (GC) still remains unclear.Materials and methods: TRIP6 expression was determined in matched GC tissues and adjacent normal tissues by western blot and real-time PCR. Then, immunohistochemistry was used to detect the expression of TRIP6 in GC patients. Statistical analysis was performed to evaluate the correlation between TRIP6 expression and clinicopathological characteristics and prognosis. Moreover, the effects of TRIP6 on GC cell proliferation and migration were also investigated by using MTT, colony formation and transwell assays.Results: We observed that the expression of TRIP6 was significantly up-regulated in GC tissues and cell ines. Our data indicated that high TRIP6 expression exhibited a significant correlation with poor prognosis for GC patients. Multivariate analysis showed that TRIP6 expression was an independent prognostic factor of the overall survival of GC patients. Furthermore, ectopic expression of TRIP6 promotes cell proliferation and migration in BGC823 cells, whereas knockdown of TRIP6 suppresses cell proliferation and migration in MKN45 cells.Conclusion: These findings demonstrate that TRIP6 exerts an important role in cancer development, which represents a potential prognostic indicator in GC.Keywords: gastric cancer, TRIP6, prognosis
format	article
author	Zhu L Xu X Tang Y Zhu X
author_facet	Zhu L Xu X Tang Y Zhu X
author_sort	Zhu L
title	TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer
title_short	TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer
title_full	TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer
title_fullStr	TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer
title_full_unstemmed	TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer
title_sort	trip6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4dd0270e51784fe48a1ca58cadd946b4
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_version_	1718400527832711168

TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer

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