Photoactivatable Cre recombinase 3.0 for in vivo mouse applications

Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved efficiency upon activation, and make mouse lines that ex...

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Autores principales:	Kumi Morikawa, Kazuhiro Furuhashi, Carmen de Sena-Tomas, Alvaro L. Garcia-Garcia, Ramsey Bekdash, Alison D. Klein, Nicholas Gallerani, Hannah E. Yamamoto, Seon-Hye E. Park, Grant S. Collins, Fuun Kawano, Moritoshi Sato, Chyuan-Sheng Lin, Kimara L. Targoff, Edmund Au, Michael C. Salling, Masayuki Yazawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dd05e1b2991499aa94c1548679f42b6
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spelling	oai:doaj.org-article:4dd05e1b2991499aa94c1548679f42b62021-12-02T15:39:17ZPhotoactivatable Cre recombinase 3.0 for in vivo mouse applications10.1038/s41467-020-16030-02041-1723https://doaj.org/article/4dd05e1b2991499aa94c1548679f42b62020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16030-0https://doaj.org/toc/2041-1723Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved efficiency upon activation, and make mouse lines that express PA-Cre 3.0 conditionally.Kumi MorikawaKazuhiro FuruhashiCarmen de Sena-TomasAlvaro L. Garcia-GarciaRamsey BekdashAlison D. KleinNicholas GalleraniHannah E. YamamotoSeon-Hye E. ParkGrant S. CollinsFuun KawanoMoritoshi SatoChyuan-Sheng LinKimara L. TargoffEdmund AuMichael C. SallingMasayuki YazawaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kumi Morikawa Kazuhiro Furuhashi Carmen de Sena-Tomas Alvaro L. Garcia-Garcia Ramsey Bekdash Alison D. Klein Nicholas Gallerani Hannah E. Yamamoto Seon-Hye E. Park Grant S. Collins Fuun Kawano Moritoshi Sato Chyuan-Sheng Lin Kimara L. Targoff Edmund Au Michael C. Salling Masayuki Yazawa Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
description	Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved efficiency upon activation, and make mouse lines that express PA-Cre 3.0 conditionally.
format	article
author	Kumi Morikawa Kazuhiro Furuhashi Carmen de Sena-Tomas Alvaro L. Garcia-Garcia Ramsey Bekdash Alison D. Klein Nicholas Gallerani Hannah E. Yamamoto Seon-Hye E. Park Grant S. Collins Fuun Kawano Moritoshi Sato Chyuan-Sheng Lin Kimara L. Targoff Edmund Au Michael C. Salling Masayuki Yazawa
author_facet	Kumi Morikawa Kazuhiro Furuhashi Carmen de Sena-Tomas Alvaro L. Garcia-Garcia Ramsey Bekdash Alison D. Klein Nicholas Gallerani Hannah E. Yamamoto Seon-Hye E. Park Grant S. Collins Fuun Kawano Moritoshi Sato Chyuan-Sheng Lin Kimara L. Targoff Edmund Au Michael C. Salling Masayuki Yazawa
author_sort	Kumi Morikawa
title	Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
title_short	Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
title_full	Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
title_fullStr	Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
title_full_unstemmed	Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
title_sort	photoactivatable cre recombinase 3.0 for in vivo mouse applications
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4dd05e1b2991499aa94c1548679f42b6
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Photoactivatable Cre recombinase 3.0 for in vivo mouse applications

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