Photoactivatable Cre recombinase 3.0 for in vivo mouse applications

Photoactivatable Cre recombinase 3.0 for in vivo mouse applications

Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved efficiency upon activation, and make mouse lines that ex...

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Autores principales: Kumi Morikawa, Kazuhiro Furuhashi, Carmen de Sena-Tomas, Alvaro L. Garcia-Garcia, Ramsey Bekdash, Alison D. Klein, Nicholas Gallerani, Hannah E. Yamamoto, Seon-Hye E. Park, Grant S. Collins, Fuun Kawano, Moritoshi Sato, Chyuan-Sheng Lin, Kimara L. Targoff, Edmund Au, Michael C. Salling, Masayuki Yazawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/4dd05e1b2991499aa94c1548679f42b6
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