A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients

BackgroundHepatocellular carcinoma (HCC) is one of the malignant tumors with high morbidity and mortality worldwide. Immunotherapy has emerged as an increasingly important cancer treatment modality. However, the potential relationship between immune genes and HCC still needs to be explored. The purp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dingde Ye, Yaping Liu, Guoqiang Li, Beicheng Sun, Jin Peng, Qingxiang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hepatocellular carcinoma immune-related genes immune-related risk score prognosis nomogram Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4dd0b97f82c843bd826d21a8701e6fa6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4dd0b97f82c843bd826d21a8701e6fa6
record_format	dspace
spelling	oai:doaj.org-article:4dd0b97f82c843bd826d21a8701e6fa62021-11-19T05:04:45ZA New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients2234-943X10.3389/fonc.2021.766072https://doaj.org/article/4dd0b97f82c843bd826d21a8701e6fa62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.766072/fullhttps://doaj.org/toc/2234-943XBackgroundHepatocellular carcinoma (HCC) is one of the malignant tumors with high morbidity and mortality worldwide. Immunotherapy has emerged as an increasingly important cancer treatment modality. However, the potential relationship between immune genes and HCC still needs to be explored. The purpose of this study is to construct a new prognostic risk signature to predict the prognosis of HCC patients based on the expression of immune-related genes (IRGs) and explore its potential mechanism.MethodsWe analyzed the gene expression data of 332 HCC patient samples and 46 adjacent normal tissues samples (Solid Tissue Normal including cirrhotic tissue) in The Cancer Genome Atlas (TCGA) database and clinical characteristics. We analyzed the gene expression data, identified differentially expressed IRGs in HCC tissues, filtered IRGs with prognostic value to construct an IRG signature, and classified patients into high and low gene expression groups based on the expression of IRGs in their tumor tissues. We also investigated the potential molecular mechanisms of IRGs through a bioinformatics approach using Protein-Protein Interaction (PPI) network, Kyoto Encyclopedia of Genes and Genomes (KEGG) database analysis and Gene Ontology (GO) database analysis. Differentially expressed IRGs associated with significant clinical outcomes (SIRGs) were identified by univariate Cox regression analysis. An immune-related risk score model (IRRSM) was established based on Lasso Cox regression analysis and multivariate Cox regression analysis. Based on the IRRSM, the immune score of the patients was calculated, and the patients were divided into high-risk and low-risk patients according to the median score, and the differences in survival between the two groups were compared. Then, the correlation analysis between the IRRSM and clinical characteristics was performed, and the IRRSM was validated using the International Cancer Genome Consortium (ICGC) database.ResultsThe IRRSM was eventually constructed and confirmed to be an independent prognostic model for HCC patients. The IRRSM was shown to be positively correlated with the infiltration of four types of immune cells.ConclusionOur results showed that some SIRGs have potential value for predicting the prognosis and clinical outcomes of HCC patients. IRGs affect the prognosis of HCC patients by regulating the tumor immune microenvironment (TIME). This study provides a new insight for immune research and treatment strategies in HCC patients.Dingde YeYaping LiuGuoqiang LiBeicheng SunJin PengQingxiang XuQingxiang XuFrontiers Media S.A.articlehepatocellular carcinomaimmune-related genesimmune-related risk scoreprognosisnomogramNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma immune-related genes immune-related risk score prognosis nomogram Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma immune-related genes immune-related risk score prognosis nomogram Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Dingde Ye Yaping Liu Guoqiang Li Beicheng Sun Jin Peng Qingxiang Xu Qingxiang Xu A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients
description	BackgroundHepatocellular carcinoma (HCC) is one of the malignant tumors with high morbidity and mortality worldwide. Immunotherapy has emerged as an increasingly important cancer treatment modality. However, the potential relationship between immune genes and HCC still needs to be explored. The purpose of this study is to construct a new prognostic risk signature to predict the prognosis of HCC patients based on the expression of immune-related genes (IRGs) and explore its potential mechanism.MethodsWe analyzed the gene expression data of 332 HCC patient samples and 46 adjacent normal tissues samples (Solid Tissue Normal including cirrhotic tissue) in The Cancer Genome Atlas (TCGA) database and clinical characteristics. We analyzed the gene expression data, identified differentially expressed IRGs in HCC tissues, filtered IRGs with prognostic value to construct an IRG signature, and classified patients into high and low gene expression groups based on the expression of IRGs in their tumor tissues. We also investigated the potential molecular mechanisms of IRGs through a bioinformatics approach using Protein-Protein Interaction (PPI) network, Kyoto Encyclopedia of Genes and Genomes (KEGG) database analysis and Gene Ontology (GO) database analysis. Differentially expressed IRGs associated with significant clinical outcomes (SIRGs) were identified by univariate Cox regression analysis. An immune-related risk score model (IRRSM) was established based on Lasso Cox regression analysis and multivariate Cox regression analysis. Based on the IRRSM, the immune score of the patients was calculated, and the patients were divided into high-risk and low-risk patients according to the median score, and the differences in survival between the two groups were compared. Then, the correlation analysis between the IRRSM and clinical characteristics was performed, and the IRRSM was validated using the International Cancer Genome Consortium (ICGC) database.ResultsThe IRRSM was eventually constructed and confirmed to be an independent prognostic model for HCC patients. The IRRSM was shown to be positively correlated with the infiltration of four types of immune cells.ConclusionOur results showed that some SIRGs have potential value for predicting the prognosis and clinical outcomes of HCC patients. IRGs affect the prognosis of HCC patients by regulating the tumor immune microenvironment (TIME). This study provides a new insight for immune research and treatment strategies in HCC patients.
format	article
author	Dingde Ye Yaping Liu Guoqiang Li Beicheng Sun Jin Peng Qingxiang Xu Qingxiang Xu
author_facet	Dingde Ye Yaping Liu Guoqiang Li Beicheng Sun Jin Peng Qingxiang Xu Qingxiang Xu
author_sort	Dingde Ye
title	A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients
title_short	A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients
title_full	A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients
title_fullStr	A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients
title_full_unstemmed	A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients
title_sort	new risk score based on eight hepatocellular carcinoma- immune gene expression can predict the prognosis of the patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4dd0b97f82c843bd826d21a8701e6fa6
work_keys_str_mv	AT dingdeye anewriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT yapingliu anewriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT guoqiangli anewriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT beichengsun anewriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT jinpeng anewriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT qingxiangxu anewriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT qingxiangxu anewriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT dingdeye newriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT yapingliu newriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT guoqiangli newriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT beichengsun newriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT jinpeng newriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT qingxiangxu newriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients AT qingxiangxu newriskscorebasedoneighthepatocellularcarcinomaimmunegeneexpressioncanpredicttheprognosisofthepatients
_version_	1718420372271923200

A New Risk Score Based on Eight Hepatocellular Carcinoma- Immune Gene Expression Can Predict the Prognosis of the Patients

Ejemplares similares