Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.

Recent experiments in the developing mammalian visual cortex have revealed that gap junctions couple excitatory cells and potentially influence the formation of chemical synapses. In particular, cells that were coupled by a gap junction during development tend to share an orientation preference and...

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Autores principales:	Jennifer Crodelle, David W McLaughlin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4dd1d51524cb4d0ca60d525a63f652fd
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spelling	oai:doaj.org-article:4dd1d51524cb4d0ca60d525a63f652fd2021-12-02T19:57:25ZModeling the role of gap junctions between excitatory neurons in the developing visual cortex.1553-734X1553-735810.1371/journal.pcbi.1007915https://doaj.org/article/4dd1d51524cb4d0ca60d525a63f652fd2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1007915https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Recent experiments in the developing mammalian visual cortex have revealed that gap junctions couple excitatory cells and potentially influence the formation of chemical synapses. In particular, cells that were coupled by a gap junction during development tend to share an orientation preference and are preferentially coupled by a chemical synapse in the adult cortex, a property that is diminished when gap junctions are blocked. In this work, we construct a simplified model of the developing mouse visual cortex including spike-timing-dependent plasticity of both the feedforward synaptic inputs and recurrent cortical synapses. We use this model to show that synchrony among gap-junction-coupled cells underlies their preference to form strong recurrent synapses and develop similar orientation preference; this effect decreases with an increase in coupling density. Additionally, we demonstrate that gap-junction coupling works, together with the relative timing of synaptic development of the feedforward and recurrent synapses, to determine the resulting cortical map of orientation preference.Jennifer CrodelleDavid W McLaughlinPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1007915 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jennifer Crodelle David W McLaughlin Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.
description	Recent experiments in the developing mammalian visual cortex have revealed that gap junctions couple excitatory cells and potentially influence the formation of chemical synapses. In particular, cells that were coupled by a gap junction during development tend to share an orientation preference and are preferentially coupled by a chemical synapse in the adult cortex, a property that is diminished when gap junctions are blocked. In this work, we construct a simplified model of the developing mouse visual cortex including spike-timing-dependent plasticity of both the feedforward synaptic inputs and recurrent cortical synapses. We use this model to show that synchrony among gap-junction-coupled cells underlies their preference to form strong recurrent synapses and develop similar orientation preference; this effect decreases with an increase in coupling density. Additionally, we demonstrate that gap-junction coupling works, together with the relative timing of synaptic development of the feedforward and recurrent synapses, to determine the resulting cortical map of orientation preference.
format	article
author	Jennifer Crodelle David W McLaughlin
author_facet	Jennifer Crodelle David W McLaughlin
author_sort	Jennifer Crodelle
title	Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.
title_short	Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.
title_full	Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.
title_fullStr	Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.
title_full_unstemmed	Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.
title_sort	modeling the role of gap junctions between excitatory neurons in the developing visual cortex.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4dd1d51524cb4d0ca60d525a63f652fd
work_keys_str_mv	AT jennifercrodelle modelingtheroleofgapjunctionsbetweenexcitatoryneuronsinthedevelopingvisualcortex AT davidwmclaughlin modelingtheroleofgapjunctionsbetweenexcitatoryneuronsinthedevelopingvisualcortex
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Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.

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