Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Spatial mapping of genomic programs in tissue cells is an important step in the understanding of organ function and disease. Here, the authors provide a spatially resolved epigenomic and transcriptomic map of human liver and show porto-central gradients in metabolic and morphogen networks and transc...

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Autores principales:	Mario Brosch, Kathrin Kattler, Alexander Herrmann, Witigo von Schönfels, Karl Nordström, Daniel Seehofer, Georg Damm, Thomas Becker, Sebastian Zeissig, Sophie Nehring, Fabian Reichel, Vincent Moser, Raghavan Veera Thangapandi, Felix Stickel, Gustavo Baretton, Christoph Röcken, Michael Muders, Madlen Matz-Soja, Michael Krawczak, Gilles Gasparoni, Hella Hartmann, Andreas Dahl, Clemens Schafmayer, Jörn Walter, Jochen Hampe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dd3544c50324379ae45d9951935389b
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spelling	oai:doaj.org-article:4dd3544c50324379ae45d9951935389b2021-12-02T17:31:16ZEpigenomic map of human liver reveals principles of zonated morphogenic and metabolic control10.1038/s41467-018-06611-52041-1723https://doaj.org/article/4dd3544c50324379ae45d9951935389b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06611-5https://doaj.org/toc/2041-1723Spatial mapping of genomic programs in tissue cells is an important step in the understanding of organ function and disease. Here, the authors provide a spatially resolved epigenomic and transcriptomic map of human liver and show porto-central gradients in metabolic and morphogen networks and transcription factor binding sites as a basis to better understand liver regeneration and function.Mario BroschKathrin KattlerAlexander HerrmannWitigo von SchönfelsKarl NordströmDaniel SeehoferGeorg DammThomas BeckerSebastian ZeissigSophie NehringFabian ReichelVincent MoserRaghavan Veera ThangapandiFelix StickelGustavo BarettonChristoph RöckenMichael MudersMadlen Matz-SojaMichael KrawczakGilles GasparoniHella HartmannAndreas DahlClemens SchafmayerJörn WalterJochen HampeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mario Brosch Kathrin Kattler Alexander Herrmann Witigo von Schönfels Karl Nordström Daniel Seehofer Georg Damm Thomas Becker Sebastian Zeissig Sophie Nehring Fabian Reichel Vincent Moser Raghavan Veera Thangapandi Felix Stickel Gustavo Baretton Christoph Röcken Michael Muders Madlen Matz-Soja Michael Krawczak Gilles Gasparoni Hella Hartmann Andreas Dahl Clemens Schafmayer Jörn Walter Jochen Hampe Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
description	Spatial mapping of genomic programs in tissue cells is an important step in the understanding of organ function and disease. Here, the authors provide a spatially resolved epigenomic and transcriptomic map of human liver and show porto-central gradients in metabolic and morphogen networks and transcription factor binding sites as a basis to better understand liver regeneration and function.
format	article
author	Mario Brosch Kathrin Kattler Alexander Herrmann Witigo von Schönfels Karl Nordström Daniel Seehofer Georg Damm Thomas Becker Sebastian Zeissig Sophie Nehring Fabian Reichel Vincent Moser Raghavan Veera Thangapandi Felix Stickel Gustavo Baretton Christoph Röcken Michael Muders Madlen Matz-Soja Michael Krawczak Gilles Gasparoni Hella Hartmann Andreas Dahl Clemens Schafmayer Jörn Walter Jochen Hampe
author_facet	Mario Brosch Kathrin Kattler Alexander Herrmann Witigo von Schönfels Karl Nordström Daniel Seehofer Georg Damm Thomas Becker Sebastian Zeissig Sophie Nehring Fabian Reichel Vincent Moser Raghavan Veera Thangapandi Felix Stickel Gustavo Baretton Christoph Röcken Michael Muders Madlen Matz-Soja Michael Krawczak Gilles Gasparoni Hella Hartmann Andreas Dahl Clemens Schafmayer Jörn Walter Jochen Hampe
author_sort	Mario Brosch
title	Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
title_short	Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
title_full	Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
title_fullStr	Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
title_full_unstemmed	Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
title_sort	epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4dd3544c50324379ae45d9951935389b
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Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

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