A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion
From single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) regulating progenitor proliferation.
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Nature Portfolio
2021
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oai:doaj.org-article:4dd4448416d0483cbbb89a084390dda12021-12-02T14:49:08ZA 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion10.1038/s41467-021-23295-62041-1723https://doaj.org/article/4dd4448416d0483cbbb89a084390dda12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23295-6https://doaj.org/toc/2041-1723From single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) regulating progenitor proliferation.Carla A. GonçalvesMichael LarsenSascha JungJohannes StratmannAkiko NakamuraMarit LeuschnerLena HersemannRashmiparvathi KesharaSigne PerlmanLene LundvallLea Langhoff ThuesenKristine Juul HareIdo AmitAnne JørgensenYung Hae KimAntonio del SolAnne Grapin-BottonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Carla A. Gonçalves Michael Larsen Sascha Jung Johannes Stratmann Akiko Nakamura Marit Leuschner Lena Hersemann Rashmiparvathi Keshara Signe Perlman Lene Lundvall Lea Langhoff Thuesen Kristine Juul Hare Ido Amit Anne Jørgensen Yung Hae Kim Antonio del Sol Anne Grapin-Botton A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| description |
From single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) regulating progenitor proliferation. |
| format |
article |
| author |
Carla A. Gonçalves Michael Larsen Sascha Jung Johannes Stratmann Akiko Nakamura Marit Leuschner Lena Hersemann Rashmiparvathi Keshara Signe Perlman Lene Lundvall Lea Langhoff Thuesen Kristine Juul Hare Ido Amit Anne Jørgensen Yung Hae Kim Antonio del Sol Anne Grapin-Botton |
| author_facet |
Carla A. Gonçalves Michael Larsen Sascha Jung Johannes Stratmann Akiko Nakamura Marit Leuschner Lena Hersemann Rashmiparvathi Keshara Signe Perlman Lene Lundvall Lea Langhoff Thuesen Kristine Juul Hare Ido Amit Anne Jørgensen Yung Hae Kim Antonio del Sol Anne Grapin-Botton |
| author_sort |
Carla A. Gonçalves |
| title |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_short |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_full |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_fullStr |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_full_unstemmed |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_sort |
3d system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4dd4448416d0483cbbb89a084390dda1 |
| work_keys_str_mv |
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