Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease

The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.

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Autores principales:	Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S. Jayawardana, Agus Salim, Natalie A. Mellett, Adam Alexander T. Smith, Gavriel Olshansky, Brian G. Drew, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Matthias Arnold, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, Peter J. Meikle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dd529924c75463b9ab9f71c074acad6
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spelling	oai:doaj.org-article:4dd529924c75463b9ab9f71c074acad62021-12-02T14:41:12ZConcordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease10.1038/s41467-020-19473-72041-1723https://doaj.org/article/4dd529924c75463b9ab9f71c074acad62020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19473-7https://doaj.org/toc/2041-1723The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.Kevin HuynhWei Ling Florence LimCorey GilesKaushala S. JayawardanaAgus SalimNatalie A. MellettAdam Alexander T. SmithGavriel OlshanskyBrian G. DrewPratishtha ChatterjeeIan MartinsSimon M. LawsAshley I. BushChristopher C. RoweVictor L. VillemagneDavid AmesColin L. MastersMatthias ArnoldKwangsik NhoAndrew J. SaykinRebecca BaillieXianlin HanRima Kaddurah-DaoukRalph N. MartinsPeter J. MeikleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin Huynh Wei Ling Florence Lim Corey Giles Kaushala S. Jayawardana Agus Salim Natalie A. Mellett Adam Alexander T. Smith Gavriel Olshansky Brian G. Drew Pratishtha Chatterjee Ian Martins Simon M. Laws Ashley I. Bush Christopher C. Rowe Victor L. Villemagne David Ames Colin L. Masters Matthias Arnold Kwangsik Nho Andrew J. Saykin Rebecca Baillie Xianlin Han Rima Kaddurah-Daouk Ralph N. Martins Peter J. Meikle Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
description	The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.
format	article
author	Kevin Huynh Wei Ling Florence Lim Corey Giles Kaushala S. Jayawardana Agus Salim Natalie A. Mellett Adam Alexander T. Smith Gavriel Olshansky Brian G. Drew Pratishtha Chatterjee Ian Martins Simon M. Laws Ashley I. Bush Christopher C. Rowe Victor L. Villemagne David Ames Colin L. Masters Matthias Arnold Kwangsik Nho Andrew J. Saykin Rebecca Baillie Xianlin Han Rima Kaddurah-Daouk Ralph N. Martins Peter J. Meikle
author_facet	Kevin Huynh Wei Ling Florence Lim Corey Giles Kaushala S. Jayawardana Agus Salim Natalie A. Mellett Adam Alexander T. Smith Gavriel Olshansky Brian G. Drew Pratishtha Chatterjee Ian Martins Simon M. Laws Ashley I. Bush Christopher C. Rowe Victor L. Villemagne David Ames Colin L. Masters Matthias Arnold Kwangsik Nho Andrew J. Saykin Rebecca Baillie Xianlin Han Rima Kaddurah-Daouk Ralph N. Martins Peter J. Meikle
author_sort	Kevin Huynh
title	Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_short	Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_full	Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_fullStr	Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_full_unstemmed	Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_sort	concordant peripheral lipidome signatures in two large clinical studies of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4dd529924c75463b9ab9f71c074acad6
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Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease

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