Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans

The membrane lipids change with ageing and function as regulatory molecules, but the underlying mechanisms are incompletely understood. Here, the authors identify C22 glucosylceramide as a regulator of the longevity transcription factor SKN-1, and show that C22 glucosylceramide regulates lifespan by...

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Autores principales:	Feng Wang, Yuxi Dai, Xufeng Zhu, Qilong Chen, Huanhu Zhu, Ben Zhou, Haiqing Tang, Shanshan Pang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dd89eb214bf41b6b156fda7115dc31d
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spelling	oai:doaj.org-article:4dd89eb214bf41b6b156fda7115dc31d2021-12-02T18:00:08ZSaturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans10.1038/s41467-021-25398-62041-1723https://doaj.org/article/4dd89eb214bf41b6b156fda7115dc31d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25398-6https://doaj.org/toc/2041-1723The membrane lipids change with ageing and function as regulatory molecules, but the underlying mechanisms are incompletely understood. Here, the authors identify C22 glucosylceramide as a regulator of the longevity transcription factor SKN-1, and show that C22 glucosylceramide regulates lifespan by controlling lysosome homeostasis and subsequent TOR activation.Feng WangYuxi DaiXufeng ZhuQilong ChenHuanhu ZhuBen ZhouHaiqing TangShanshan PangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Wang Yuxi Dai Xufeng Zhu Qilong Chen Huanhu Zhu Ben Zhou Haiqing Tang Shanshan Pang Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
description	The membrane lipids change with ageing and function as regulatory molecules, but the underlying mechanisms are incompletely understood. Here, the authors identify C22 glucosylceramide as a regulator of the longevity transcription factor SKN-1, and show that C22 glucosylceramide regulates lifespan by controlling lysosome homeostasis and subsequent TOR activation.
format	article
author	Feng Wang Yuxi Dai Xufeng Zhu Qilong Chen Huanhu Zhu Ben Zhou Haiqing Tang Shanshan Pang
author_facet	Feng Wang Yuxi Dai Xufeng Zhu Qilong Chen Huanhu Zhu Ben Zhou Haiqing Tang Shanshan Pang
author_sort	Feng Wang
title	Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
title_short	Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
title_full	Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
title_fullStr	Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
title_full_unstemmed	Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans
title_sort	saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived c. elegans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4dd89eb214bf41b6b156fda7115dc31d
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Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans

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