Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis

Abstract The role of lipoprotein-A [Lp (a)] as a risk factor for stroke is less well documented than for coronary heart disease. Hence, we conducted a systematic review and meta-analysis for the published observational studies in order to investigate the association of Lp (a) levels with the risk of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pradeep Kumar, Priyanka Swarnkar, Shubham Misra, Manabesh Nath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ddbce29af9a430c8b3cf87a81a1f932
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4ddbce29af9a430c8b3cf87a81a1f932
record_format	dspace
spelling	oai:doaj.org-article:4ddbce29af9a430c8b3cf87a81a1f9322021-12-02T14:53:48ZLipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis10.1038/s41598-021-95141-02045-2322https://doaj.org/article/4ddbce29af9a430c8b3cf87a81a1f9322021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95141-0https://doaj.org/toc/2045-2322Abstract The role of lipoprotein-A [Lp (a)] as a risk factor for stroke is less well documented than for coronary heart disease. Hence, we conducted a systematic review and meta-analysis for the published observational studies in order to investigate the association of Lp (a) levels with the risk of stroke and its subtypes. In our meta-analysis, 41 studies involving 7874 ischemic stroke (IS) patients and 32,138 controls; 13 studies for the IS subtypes based on TOAST classification and 7 studies with 871 Intracerebral hemorrhage (ICH) cases and 2865 control subjects were included. A significant association between increased levels of Lp (a) and risk of IS as compared to control subjects was observed (standardized mean difference (SMD) 0.76; 95% confidence interval (CIs) 0.53–0.99). Lp (a) levels were also found to be significantly associated with the risk of large artery atherosclerosis (LAA) subtype of IS (SMD 0.68; 95% CI 0.01–1.34) as well as significantly associated with the risk of ICH (SMD 0.65; 95% CI 0.13–1.17) as compared to controls. Increased Lp (a) levels could be considered as a predictive marker for identifying individuals who are at risk of developing IS, LAA and ICH.Pradeep KumarPriyanka SwarnkarShubham MisraManabesh NathNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pradeep Kumar Priyanka Swarnkar Shubham Misra Manabesh Nath Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis
description	Abstract The role of lipoprotein-A [Lp (a)] as a risk factor for stroke is less well documented than for coronary heart disease. Hence, we conducted a systematic review and meta-analysis for the published observational studies in order to investigate the association of Lp (a) levels with the risk of stroke and its subtypes. In our meta-analysis, 41 studies involving 7874 ischemic stroke (IS) patients and 32,138 controls; 13 studies for the IS subtypes based on TOAST classification and 7 studies with 871 Intracerebral hemorrhage (ICH) cases and 2865 control subjects were included. A significant association between increased levels of Lp (a) and risk of IS as compared to control subjects was observed (standardized mean difference (SMD) 0.76; 95% confidence interval (CIs) 0.53–0.99). Lp (a) levels were also found to be significantly associated with the risk of large artery atherosclerosis (LAA) subtype of IS (SMD 0.68; 95% CI 0.01–1.34) as well as significantly associated with the risk of ICH (SMD 0.65; 95% CI 0.13–1.17) as compared to controls. Increased Lp (a) levels could be considered as a predictive marker for identifying individuals who are at risk of developing IS, LAA and ICH.
format	article
author	Pradeep Kumar Priyanka Swarnkar Shubham Misra Manabesh Nath
author_facet	Pradeep Kumar Priyanka Swarnkar Shubham Misra Manabesh Nath
author_sort	Pradeep Kumar
title	Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis
title_short	Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis
title_full	Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis
title_fullStr	Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis
title_full_unstemmed	Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis
title_sort	lipoprotein (a) level as a risk factor for stroke and its subtype: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ddbce29af9a430c8b3cf87a81a1f932
work_keys_str_mv	AT pradeepkumar lipoproteinalevelasariskfactorforstrokeanditssubtypeasystematicreviewandmetaanalysis AT priyankaswarnkar lipoproteinalevelasariskfactorforstrokeanditssubtypeasystematicreviewandmetaanalysis AT shubhammisra lipoproteinalevelasariskfactorforstrokeanditssubtypeasystematicreviewandmetaanalysis AT manabeshnath lipoproteinalevelasariskfactorforstrokeanditssubtypeasystematicreviewandmetaanalysis
_version_	1718389381299961856

Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis

Ejemplares similares