Proteins associated with incident metabolic syndrome in population-based cohorts

Abstract Background The metabolic syndrome (MetS) identifies persons with clustering of multiple cardiometabolic risk factors. The underlying pathology inducing this clustering is not fully known. We used a targeted proteomics assay to identify associations of circulating proteins with MetS and its...

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Autores principales:	Lars Lind, Johan Sundström, Johan Ärnlöv
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Metabolic syndrome Protein Interleukin Epidemiology Prospective Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/4ddc44c466d842ab9f4e924599d5dbab
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spelling	oai:doaj.org-article:4ddc44c466d842ab9f4e924599d5dbab2021-11-14T12:38:52ZProteins associated with incident metabolic syndrome in population-based cohorts10.1186/s13098-021-00752-21758-5996https://doaj.org/article/4ddc44c466d842ab9f4e924599d5dbab2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13098-021-00752-2https://doaj.org/toc/1758-5996Abstract Background The metabolic syndrome (MetS) identifies persons with clustering of multiple cardiometabolic risk factors. The underlying pathology inducing this clustering is not fully known. We used a targeted proteomics assay to identify associations of circulating proteins with MetS and its components, cross-sectionally and longitudinally. Methods We explored and validated associations of 86 cardiovascular proteins, assessed using a proximity extension assay, with the MetS in two independent cohorts; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, n = 996) and Uppsala Longitudinal Study of Adult Men (ULSAM, n = 785). The analyses were adjusted for smoking, exercise habits, education, and energy and alcohol intake. Results Nine proteins were associated with all five components of the MetS in PIVUS using FDR < 0.05 in a cross-sectional analysis. Of those nine proteins, only Interleukin-1 receptor antagonist protein (IL-1RA) was associated with all five components of the MetS in ULSAM using p < 0.05. IL-1RA levels were associated with incident MetS (n = 109) in PIVUS during a 5-year follow-up (HR 1.76 for a 1 SD change (95% CI 1.38, 2.24), p = 4.3*10–6). IL-1RA was however not causally related to MetS in a two-sample Mendelian randomization analysis using published data. Conclusion Circulating IL-1RA was related to all five components of the MetS in a cross-sectional analysis in two independent samples, as well as to incident MetS in a longitudinal analysis. However, Mendelian randomization analyses did not provide support for a causal role for IL-1RA in the development of MetS.Lars LindJohan SundströmJohan ÄrnlövBMCarticleMetabolic syndromeProteinInterleukinEpidemiologyProspectiveNutritional diseases. Deficiency diseasesRC620-627ENDiabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metabolic syndrome Protein Interleukin Epidemiology Prospective Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Metabolic syndrome Protein Interleukin Epidemiology Prospective Nutritional diseases. Deficiency diseases RC620-627 Lars Lind Johan Sundström Johan Ärnlöv Proteins associated with incident metabolic syndrome in population-based cohorts
description	Abstract Background The metabolic syndrome (MetS) identifies persons with clustering of multiple cardiometabolic risk factors. The underlying pathology inducing this clustering is not fully known. We used a targeted proteomics assay to identify associations of circulating proteins with MetS and its components, cross-sectionally and longitudinally. Methods We explored and validated associations of 86 cardiovascular proteins, assessed using a proximity extension assay, with the MetS in two independent cohorts; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, n = 996) and Uppsala Longitudinal Study of Adult Men (ULSAM, n = 785). The analyses were adjusted for smoking, exercise habits, education, and energy and alcohol intake. Results Nine proteins were associated with all five components of the MetS in PIVUS using FDR < 0.05 in a cross-sectional analysis. Of those nine proteins, only Interleukin-1 receptor antagonist protein (IL-1RA) was associated with all five components of the MetS in ULSAM using p < 0.05. IL-1RA levels were associated with incident MetS (n = 109) in PIVUS during a 5-year follow-up (HR 1.76 for a 1 SD change (95% CI 1.38, 2.24), p = 4.3*10–6). IL-1RA was however not causally related to MetS in a two-sample Mendelian randomization analysis using published data. Conclusion Circulating IL-1RA was related to all five components of the MetS in a cross-sectional analysis in two independent samples, as well as to incident MetS in a longitudinal analysis. However, Mendelian randomization analyses did not provide support for a causal role for IL-1RA in the development of MetS.
format	article
author	Lars Lind Johan Sundström Johan Ärnlöv
author_facet	Lars Lind Johan Sundström Johan Ärnlöv
author_sort	Lars Lind
title	Proteins associated with incident metabolic syndrome in population-based cohorts
title_short	Proteins associated with incident metabolic syndrome in population-based cohorts
title_full	Proteins associated with incident metabolic syndrome in population-based cohorts
title_fullStr	Proteins associated with incident metabolic syndrome in population-based cohorts
title_full_unstemmed	Proteins associated with incident metabolic syndrome in population-based cohorts
title_sort	proteins associated with incident metabolic syndrome in population-based cohorts
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4ddc44c466d842ab9f4e924599d5dbab
work_keys_str_mv	AT larslind proteinsassociatedwithincidentmetabolicsyndromeinpopulationbasedcohorts AT johansundstrom proteinsassociatedwithincidentmetabolicsyndromeinpopulationbasedcohorts AT johanarnlov proteinsassociatedwithincidentmetabolicsyndromeinpopulationbasedcohorts
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Proteins associated with incident metabolic syndrome in population-based cohorts

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