Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness

Abstract Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI r in assessing arterial stiffness is limited. This study pr...

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Autores principales:	Yang Yao, Liling Hao, Lisheng Xu, Yahui Zhang, Lin Qi, Yingxian Sun, Benqiang Yang, Frans N. van de Vosse, Yudong Yao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4de397120ea44f88bc93232a1fa9a794
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spelling	oai:doaj.org-article:4de397120ea44f88bc93232a1fa9a7942021-12-02T16:07:06ZDiastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness10.1038/s41598-017-06094-22045-2322https://doaj.org/article/4de397120ea44f88bc93232a1fa9a7942017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06094-2https://doaj.org/toc/2045-2322Abstract Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI r in assessing arterial stiffness is limited. This study proposes a novel index AI rd , a combination of AI r and diastolic augmentation index (AI d ) with a weight α, to achieve better performance over AI r in assessing arterial stiffness. 120 subjects (43 ± 21 years old) were enrolled. The best-fit α is determined by the best correlation coefficient between AI rd and cfPWV. The performance of the method was tested using the 12-fold cross validation method. AI rd (r = 0.68, P < 0.001) shows a stronger correlation with cfPWV and a narrower prediction interval than AI r (r = 0.61, P < 0.001), AI d (r = −0.17, P = 0.06), the central augmentation index (AI c ) (r = 0.61, P < 0.001) or AI c normalized for heart rate of 75 bpm (r = 0.65, P < 0.001). Compared with AI r (age, P < 0.001; gender, P < 0.001; heart rate, P < 0.001; diastolic blood pressure, P < 0.001; weight, P = 0.001), AI rd has fewer confounding factors (age, P < 0.001; gender, P < 0.001). In conclusion, AI rd derives performance improvement in assessing arterial stiffness, with a stronger correlation with cfPWV and fewer confounding factors.Yang YaoLiling HaoLisheng XuYahui ZhangLin QiYingxian SunBenqiang YangFrans N. van de VosseYudong YaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Yao Liling Hao Lisheng Xu Yahui Zhang Lin Qi Yingxian Sun Benqiang Yang Frans N. van de Vosse Yudong Yao Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness
description	Abstract Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI r in assessing arterial stiffness is limited. This study proposes a novel index AI rd , a combination of AI r and diastolic augmentation index (AI d ) with a weight α, to achieve better performance over AI r in assessing arterial stiffness. 120 subjects (43 ± 21 years old) were enrolled. The best-fit α is determined by the best correlation coefficient between AI rd and cfPWV. The performance of the method was tested using the 12-fold cross validation method. AI rd (r = 0.68, P < 0.001) shows a stronger correlation with cfPWV and a narrower prediction interval than AI r (r = 0.61, P < 0.001), AI d (r = −0.17, P = 0.06), the central augmentation index (AI c ) (r = 0.61, P < 0.001) or AI c normalized for heart rate of 75 bpm (r = 0.65, P < 0.001). Compared with AI r (age, P < 0.001; gender, P < 0.001; heart rate, P < 0.001; diastolic blood pressure, P < 0.001; weight, P = 0.001), AI rd has fewer confounding factors (age, P < 0.001; gender, P < 0.001). In conclusion, AI rd derives performance improvement in assessing arterial stiffness, with a stronger correlation with cfPWV and fewer confounding factors.
format	article
author	Yang Yao Liling Hao Lisheng Xu Yahui Zhang Lin Qi Yingxian Sun Benqiang Yang Frans N. van de Vosse Yudong Yao
author_facet	Yang Yao Liling Hao Lisheng Xu Yahui Zhang Lin Qi Yingxian Sun Benqiang Yang Frans N. van de Vosse Yudong Yao
author_sort	Yang Yao
title	Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness
title_short	Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness
title_full	Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness
title_fullStr	Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness
title_full_unstemmed	Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness
title_sort	diastolic augmentation index improves radial augmentation index in assessing arterial stiffness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4de397120ea44f88bc93232a1fa9a794
work_keys_str_mv	AT yangyao diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT lilinghao diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT lishengxu diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT yahuizhang diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT linqi diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT yingxiansun diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT benqiangyang diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT fransnvandevosse diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness AT yudongyao diastolicaugmentationindeximprovesradialaugmentationindexinassessingarterialstiffness
_version_	1718384715408343040

Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness

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