Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions

Fibroblastic reticular cells (FRCs) are important regulators of T cell survival, proliferation, and migration in secondary lymphoid organs, but their role in HIV infection isn’t studied. Here, Murakami et al. show that FRCs enhance HIV spread via CD44- and hyaluronan-mediated trans-infection.

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Autores principales:	Tomoyuki Murakami, Jiwon Kim, Yi Li, Glenn Edward Green, Ariella Shikanov, Akira Ono
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4de510ff77464bb39b192be36b07681e
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spelling	oai:doaj.org-article:4de510ff77464bb39b192be36b07681e2021-12-02T17:32:44ZSecondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions10.1038/s41467-018-04846-w2041-1723https://doaj.org/article/4de510ff77464bb39b192be36b07681e2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04846-whttps://doaj.org/toc/2041-1723Fibroblastic reticular cells (FRCs) are important regulators of T cell survival, proliferation, and migration in secondary lymphoid organs, but their role in HIV infection isn’t studied. Here, Murakami et al. show that FRCs enhance HIV spread via CD44- and hyaluronan-mediated trans-infection.Tomoyuki MurakamiJiwon KimYi LiGlenn Edward GreenAriella ShikanovAkira OnoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomoyuki Murakami Jiwon Kim Yi Li Glenn Edward Green Ariella Shikanov Akira Ono Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions
description	Fibroblastic reticular cells (FRCs) are important regulators of T cell survival, proliferation, and migration in secondary lymphoid organs, but their role in HIV infection isn’t studied. Here, Murakami et al. show that FRCs enhance HIV spread via CD44- and hyaluronan-mediated trans-infection.
format	article
author	Tomoyuki Murakami Jiwon Kim Yi Li Glenn Edward Green Ariella Shikanov Akira Ono
author_facet	Tomoyuki Murakami Jiwon Kim Yi Li Glenn Edward Green Ariella Shikanov Akira Ono
author_sort	Tomoyuki Murakami
title	Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions
title_short	Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions
title_full	Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions
title_fullStr	Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions
title_full_unstemmed	Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions
title_sort	secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of hiv-1 via cd44-hyaluronan interactions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4de510ff77464bb39b192be36b07681e
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Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions

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