Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study

Abstract The ventricular arrhythmia (VA)–chronic obstructive pulmonary disease (COPD) association and related risk factors remain unclear. Using 2001–2012 data from National Health Insurance Research Database, we retrospectively reviewed 71,838 patients diagnosed as having COPD and 71,838 age- and s...

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Autores principales:	Chun-Chao Chen, Cheng-Hsin Lin, Wen-Rui Hao, Chun-Chih Chiu, Yu-Ann Fang, Ju-Chi Liu, Li-Chin Sung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/4de721a63df448229b60539148f7661e
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spelling	oai:doaj.org-article:4de721a63df448229b60539148f7661e2021-12-02T13:30:27ZAssociation between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study10.1038/s41533-021-00221-32055-1010https://doaj.org/article/4de721a63df448229b60539148f7661e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41533-021-00221-3https://doaj.org/toc/2055-1010Abstract The ventricular arrhythmia (VA)–chronic obstructive pulmonary disease (COPD) association and related risk factors remain unclear. Using 2001–2012 data from National Health Insurance Research Database, we retrospectively reviewed 71,838 patients diagnosed as having COPD and 71,838 age- and sex-matched controls. After adjustments for comorbidities, medication, urbanization level, and monthly income, patients with COPD had higher incidence rates of VA than did the controls (adjusted hazard ratio [aHR] [95% confidence interval (CI)]: 1.45 [1.25–1.68]). More hospitalization or emergency visits because of acute COPD exacerbation (aHRs [95% CIs] for first, second, and third visits: 1.28 [1.08–1.50], 1.75 [1.32–2.32], and 1.88 [1.46–2.41], respectively) and asthma–COPD overlap (aHR [95% CI]: 1.49 [1.25–1.79]) were associated with high VA risk in patients with COPD. In the multivariate analysis, heart failure (aHR [95% CI]: 2.37 [1.79–3.14]), diabetes (aHR [95% CI]:1.64 [1.29–2.08]), age ≥75 (aHR [95% CI]: 2.48 [1.68–3.67]), male (aHR [95% CI]: 1.69[1.34–2.12]), and class III antiarrhythmic drug use (aHR [95% CI]: 2.49 [1.88–3.28]) are the most significant risk factors of new onset of VA in patients with COPD.Chun-Chao ChenCheng-Hsin LinWen-Rui HaoChun-Chih ChiuYu-Ann FangJu-Chi LiuLi-Chin SungNature PortfolioarticleDiseases of the respiratory systemRC705-779ENnpj Primary Care Respiratory Medicine, Vol 31, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Chun-Chao Chen Cheng-Hsin Lin Wen-Rui Hao Chun-Chih Chiu Yu-Ann Fang Ju-Chi Liu Li-Chin Sung Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study
description	Abstract The ventricular arrhythmia (VA)–chronic obstructive pulmonary disease (COPD) association and related risk factors remain unclear. Using 2001–2012 data from National Health Insurance Research Database, we retrospectively reviewed 71,838 patients diagnosed as having COPD and 71,838 age- and sex-matched controls. After adjustments for comorbidities, medication, urbanization level, and monthly income, patients with COPD had higher incidence rates of VA than did the controls (adjusted hazard ratio [aHR] [95% confidence interval (CI)]: 1.45 [1.25–1.68]). More hospitalization or emergency visits because of acute COPD exacerbation (aHRs [95% CIs] for first, second, and third visits: 1.28 [1.08–1.50], 1.75 [1.32–2.32], and 1.88 [1.46–2.41], respectively) and asthma–COPD overlap (aHR [95% CI]: 1.49 [1.25–1.79]) were associated with high VA risk in patients with COPD. In the multivariate analysis, heart failure (aHR [95% CI]: 2.37 [1.79–3.14]), diabetes (aHR [95% CI]:1.64 [1.29–2.08]), age ≥75 (aHR [95% CI]: 2.48 [1.68–3.67]), male (aHR [95% CI]: 1.69[1.34–2.12]), and class III antiarrhythmic drug use (aHR [95% CI]: 2.49 [1.88–3.28]) are the most significant risk factors of new onset of VA in patients with COPD.
format	article
author	Chun-Chao Chen Cheng-Hsin Lin Wen-Rui Hao Chun-Chih Chiu Yu-Ann Fang Ju-Chi Liu Li-Chin Sung
author_facet	Chun-Chao Chen Cheng-Hsin Lin Wen-Rui Hao Chun-Chih Chiu Yu-Ann Fang Ju-Chi Liu Li-Chin Sung
author_sort	Chun-Chao Chen
title	Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study
title_short	Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study
title_full	Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study
title_fullStr	Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study
title_full_unstemmed	Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study
title_sort	association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4de721a63df448229b60539148f7661e
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Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study

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