Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological lowering of glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, strikingly improves glycemic control. Here we studied the effects of AMP-DNM on adipo...

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Main Authors: Marco van Eijk, Jan Aten, Nora Bijl, Roelof Ottenhoff, Cindy P A A van Roomen, Peter F Dubbelhuis, Ingar Seeman, Karen Ghauharali-van der Vlugt, Hermen S Overkleeft, Cynthia Arbeeny, Albert K Groen, Johannes M F G Aerts
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2009
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/4de7292dc62c4bccba10a1b9b8fc6b87
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