Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological lowering of glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, strikingly improves glycemic control. Here we studied the effects of AMP-DNM on adipo...

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Autores principales:	Marco van Eijk, Jan Aten, Nora Bijl, Roelof Ottenhoff, Cindy P A A van Roomen, Peter F Dubbelhuis, Ingar Seeman, Karen Ghauharali-van der Vlugt, Hermen S Overkleeft, Cynthia Arbeeny, Albert K Groen, Johannes M F G Aerts
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4de7292dc62c4bccba10a1b9b8fc6b87
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Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

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