Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model

Abstract The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vi...

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Autores principales:	Govindarajan Karthivashan, Shin-Young Park, Mee-Hyang Kweon, Joonsoo Kim, Md. Ezazul Haque, Duk-Yeon Cho, In-Su Kim, Eun-Ah Cho, Palanivel Ganesan, Dong-Kug Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4de9590a79854e58ab7d1a93b5d01c73
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spelling	oai:doaj.org-article:4de9590a79854e58ab7d1a93b5d01c732021-12-02T11:40:46ZAmeliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model10.1038/s41598-018-25381-02045-2322https://doaj.org/article/4de9590a79854e58ab7d1a93b5d01c732018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25381-0https://doaj.org/toc/2045-2322Abstract The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and chromatographic profiling of desalted and enzyme-digested SE ethanol extract (SE-EE). Subsequently, we evaluated the anti-neuroinflammatory and ameliorative potential of SE-EE in LPS-inflicted BV-2 microglial cells and scopolamine-induced amnesic C57/BL6N mice, respectively. SE-EE possess considerable polyphenols and flavonoids that are supposedly responsible to improve its bio-efficacy. SE-EE dose-dependently attenuated LPS-induced inflammation in BV-2 cells, significantly repressed behavioural/cognitive impairment, dose-dependently regulated the cholinergic function, suppressed oxidative stress markers, regulated inflammatory cytokines/associated proteins expression and effectively ameliorated p-CREB/BDNF levels, neurogenesis (DCX stain), neuron proliferation (Ki67 stain) in scopolamine-administered mice. Thus, SE-EE extract shows promising multifactorial disease modifying activities and can be further developed as an effective functional food, drug candidate, or supplemental therapy to treat neuroinflammatory mediated disorders.Govindarajan KarthivashanShin-Young ParkMee-Hyang KweonJoonsoo KimMd. Ezazul HaqueDuk-Yeon ChoIn-Su KimEun-Ah ChoPalanivel GanesanDong-Kug ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Govindarajan Karthivashan Shin-Young Park Mee-Hyang Kweon Joonsoo Kim Md. Ezazul Haque Duk-Yeon Cho In-Su Kim Eun-Ah Cho Palanivel Ganesan Dong-Kug Choi Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model
description	Abstract The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and chromatographic profiling of desalted and enzyme-digested SE ethanol extract (SE-EE). Subsequently, we evaluated the anti-neuroinflammatory and ameliorative potential of SE-EE in LPS-inflicted BV-2 microglial cells and scopolamine-induced amnesic C57/BL6N mice, respectively. SE-EE possess considerable polyphenols and flavonoids that are supposedly responsible to improve its bio-efficacy. SE-EE dose-dependently attenuated LPS-induced inflammation in BV-2 cells, significantly repressed behavioural/cognitive impairment, dose-dependently regulated the cholinergic function, suppressed oxidative stress markers, regulated inflammatory cytokines/associated proteins expression and effectively ameliorated p-CREB/BDNF levels, neurogenesis (DCX stain), neuron proliferation (Ki67 stain) in scopolamine-administered mice. Thus, SE-EE extract shows promising multifactorial disease modifying activities and can be further developed as an effective functional food, drug candidate, or supplemental therapy to treat neuroinflammatory mediated disorders.
format	article
author	Govindarajan Karthivashan Shin-Young Park Mee-Hyang Kweon Joonsoo Kim Md. Ezazul Haque Duk-Yeon Cho In-Su Kim Eun-Ah Cho Palanivel Ganesan Dong-Kug Choi
author_facet	Govindarajan Karthivashan Shin-Young Park Mee-Hyang Kweon Joonsoo Kim Md. Ezazul Haque Duk-Yeon Cho In-Su Kim Eun-Ah Cho Palanivel Ganesan Dong-Kug Choi
author_sort	Govindarajan Karthivashan
title	Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model
title_short	Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model
title_full	Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model
title_fullStr	Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model
title_full_unstemmed	Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model
title_sort	ameliorative potential of desalted salicornia europaea l. extract in multifaceted alzheimer’s-like scopolamine-induced amnesic mice model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4de9590a79854e58ab7d1a93b5d01c73
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Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model

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