HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties

Mehran Mehrabanian1, Mojtaba Nasr-Esfahani21Member of Young Researchers Club, Najafabad Branch, Islamic Azad University, Isfahan, Iran; 2Department of Materials Science and Engineering, Najafabad Branch, Islamic Azad University, Isfahan, IranAbstract: Nanohydroxyapatite (n-HA)/nylon 6,6 composite sc...

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Autores principales:	Mehrabanian M, Nasr-Esfahani M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4dec11288327491fa08b629fe290892f
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spelling	oai:doaj.org-article:4dec11288327491fa08b629fe290892f2021-12-02T00:31:18ZHA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties1176-91141178-2013https://doaj.org/article/4dec11288327491fa08b629fe290892f2011-08-01T00:00:00Zhttp://www.dovepress.com/hanylon-66-porous-scaffolds-fabricated-by-salt-leachingsolvent-casting-a8066https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mehran Mehrabanian1, Mojtaba Nasr-Esfahani21Member of Young Researchers Club, Najafabad Branch, Islamic Azad University, Isfahan, Iran; 2Department of Materials Science and Engineering, Najafabad Branch, Islamic Azad University, Isfahan, IranAbstract: Nanohydroxyapatite (n-HA)/nylon 6,6 composite scaffolds were produced by means of the salt-leaching/solvent casting technique. NaCl with a distinct range size was used with the aim of optimizing the pore network. Composite powders with different n-HA contents (40%, 60%) for scaffold fabrication were synthesized and tested. The composite scaffolds thus obtained were characterized for their microstructure, mechanical stability and strength, and bioactivity. The microstructure of the composite scaffolds possessed a well-developed interconnected porosity with approximate optimal pore size ranging from 200 to 500 &micro;m, ideal for bone regeneration and vascularization. The mechanical properties of the composite scaffolds were evaluated by compressive strength and modulus tests, and the results confirmed their similarity to cortical bone. To characterize bioactivity, the composite scaffolds were immersed in simulated body fluid for different lengths of time and results monitored by scanning electron microscopy and energy dispersive X-ray microanalysis to determine formation of an apatite layer on the scaffold surface.Keywords: scaffold, nanohydroxyapatite, nylon 6,6, salt-leaching/solvent casting, bioactivityMehrabanian MNasr-Esfahani MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1651-1659 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mehrabanian M Nasr-Esfahani M HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties
description	Mehran Mehrabanian1, Mojtaba Nasr-Esfahani21Member of Young Researchers Club, Najafabad Branch, Islamic Azad University, Isfahan, Iran; 2Department of Materials Science and Engineering, Najafabad Branch, Islamic Azad University, Isfahan, IranAbstract: Nanohydroxyapatite (n-HA)/nylon 6,6 composite scaffolds were produced by means of the salt-leaching/solvent casting technique. NaCl with a distinct range size was used with the aim of optimizing the pore network. Composite powders with different n-HA contents (40%, 60%) for scaffold fabrication were synthesized and tested. The composite scaffolds thus obtained were characterized for their microstructure, mechanical stability and strength, and bioactivity. The microstructure of the composite scaffolds possessed a well-developed interconnected porosity with approximate optimal pore size ranging from 200 to 500 &micro;m, ideal for bone regeneration and vascularization. The mechanical properties of the composite scaffolds were evaluated by compressive strength and modulus tests, and the results confirmed their similarity to cortical bone. To characterize bioactivity, the composite scaffolds were immersed in simulated body fluid for different lengths of time and results monitored by scanning electron microscopy and energy dispersive X-ray microanalysis to determine formation of an apatite layer on the scaffold surface.Keywords: scaffold, nanohydroxyapatite, nylon 6,6, salt-leaching/solvent casting, bioactivity
format	article
author	Mehrabanian M Nasr-Esfahani M
author_facet	Mehrabanian M Nasr-Esfahani M
author_sort	Mehrabanian M
title	HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties
title_short	HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties
title_full	HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties
title_fullStr	HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties
title_full_unstemmed	HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties
title_sort	ha/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/4dec11288327491fa08b629fe290892f
work_keys_str_mv	AT mehrabanianm hanylon66porousscaffoldsfabricatedbysaltleachingsolventcastingtechniqueeffectofnanosizedfillercontentonscaffoldproperties AT nasresfahanim hanylon66porousscaffoldsfabricatedbysaltleachingsolventcastingtechniqueeffectofnanosizedfillercontentonscaffoldproperties
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HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties

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