Total and partial IgA deficiency in blood serum in children. Clinical observation

We conducted a 13-year observation of 9 patients with total and partial IgA deficiency. The age of children in primary treatment was 3.0 ± 0.2 years on average. The observation was carried out on the basis of the outpatient service of Irkutsk State Regional Children's Clinical Hospital. The exa...

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Autores principales:	T. B. Pavlova, V. M. Shinkareva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	immunoglobulin a deficiency primary immunodeficiency clinical observation children Science Q
Acceso en línea:	https://doaj.org/article/4dedf3076c9c472abc92fddd3bf3e72d
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spelling	oai:doaj.org-article:4dedf3076c9c472abc92fddd3bf3e72d2021-11-23T06:14:37ZTotal and partial IgA deficiency in blood serum in children. Clinical observation2541-94202587-959610.12737/article_59f036051f3b29.73512973https://doaj.org/article/4dedf3076c9c472abc92fddd3bf3e72d2017-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/402https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596We conducted a 13-year observation of 9 patients with total and partial IgA deficiency. The age of children in primary treatment was 3.0 ± 0.2 years on average. The observation was carried out on the basis of the outpatient service of Irkutsk State Regional Children's Clinical Hospital. The examination included immunological, clinical-allergic and functional methods of research. To assess the humoral link of the immune system, serum Ig concentrations of classes A, M, G (mg/dl) were determined in the first 3 years annually, and then every 2-3 years. As a result, it was found that among the patients with IgA immunodeficiency, boys predominate over girls in a ratio of 3.5:1. With a partial IgA deficiency detected at an early age, the majority of patients have normalization of their IgA level, but sometimes there is a transformation into a selective IgA deficiency with an increase in the number of clinical markers of this condition. With a selective deficiency of IgA detected at an early age, half of the patients have normalization of the IgA level by the age of adolescence, but another half still maintain a significant decrease in serum IgA. Clinical manifestations in the majority of observed children with selective IgA deficiency included atopic respiratory diseases - bronchial asthma and allergic rhinitis, in one case - diabetes mellitus. In some children, the selective deficiency of IgA was asymptomatic.T. B. PavlovaV. M. ShinkarevaScientific Сentre for Family Health and Human Reproduction Problemsarticleimmunoglobulin a deficiencyprimary immunodeficiencyclinical observationchildrenScienceQRUActa Biomedica Scientifica, Vol 2, Iss 3, Pp 110-113 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunoglobulin a deficiency primary immunodeficiency clinical observation children Science Q
spellingShingle	immunoglobulin a deficiency primary immunodeficiency clinical observation children Science Q T. B. Pavlova V. M. Shinkareva Total and partial IgA deficiency in blood serum in children. Clinical observation
description	We conducted a 13-year observation of 9 patients with total and partial IgA deficiency. The age of children in primary treatment was 3.0 ± 0.2 years on average. The observation was carried out on the basis of the outpatient service of Irkutsk State Regional Children's Clinical Hospital. The examination included immunological, clinical-allergic and functional methods of research. To assess the humoral link of the immune system, serum Ig concentrations of classes A, M, G (mg/dl) were determined in the first 3 years annually, and then every 2-3 years. As a result, it was found that among the patients with IgA immunodeficiency, boys predominate over girls in a ratio of 3.5:1. With a partial IgA deficiency detected at an early age, the majority of patients have normalization of their IgA level, but sometimes there is a transformation into a selective IgA deficiency with an increase in the number of clinical markers of this condition. With a selective deficiency of IgA detected at an early age, half of the patients have normalization of the IgA level by the age of adolescence, but another half still maintain a significant decrease in serum IgA. Clinical manifestations in the majority of observed children with selective IgA deficiency included atopic respiratory diseases - bronchial asthma and allergic rhinitis, in one case - diabetes mellitus. In some children, the selective deficiency of IgA was asymptomatic.
format	article
author	T. B. Pavlova V. M. Shinkareva
author_facet	T. B. Pavlova V. M. Shinkareva
author_sort	T. B. Pavlova
title	Total and partial IgA deficiency in blood serum in children. Clinical observation
title_short	Total and partial IgA deficiency in blood serum in children. Clinical observation
title_full	Total and partial IgA deficiency in blood serum in children. Clinical observation
title_fullStr	Total and partial IgA deficiency in blood serum in children. Clinical observation
title_full_unstemmed	Total and partial IgA deficiency in blood serum in children. Clinical observation
title_sort	total and partial iga deficiency in blood serum in children. clinical observation
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/4dedf3076c9c472abc92fddd3bf3e72d
work_keys_str_mv	AT tbpavlova totalandpartialigadeficiencyinbloodseruminchildrenclinicalobservation AT vmshinkareva totalandpartialigadeficiencyinbloodseruminchildrenclinicalobservation
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Total and partial IgA deficiency in blood serum in children. Clinical observation

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