Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions

Abstract Modern day hospital treatments aim at developing electrochemical biosensors for early diagnosis of diseases using unconventional human bio-fluids like sweat and saliva by monitoring the electron transfer reactions of target analytes. Such kinds of health care diagnostics primarily avoid the...

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Autores principales:	P. Krishnaveni, V. Ganesh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4dee9162c4f341fdb09acd62fb598931
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spelling	oai:doaj.org-article:4dee9162c4f341fdb09acd62fb5989312021-12-02T14:17:16ZElectron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions10.1038/s41598-021-86866-z2045-2322https://doaj.org/article/4dee9162c4f341fdb09acd62fb5989312021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86866-zhttps://doaj.org/toc/2045-2322Abstract Modern day hospital treatments aim at developing electrochemical biosensors for early diagnosis of diseases using unconventional human bio-fluids like sweat and saliva by monitoring the electron transfer reactions of target analytes. Such kinds of health care diagnostics primarily avoid the usage of human blood and urine samples. In this context, here we have investigated the electron transfer reaction of a well-known and commonly used redox probe namely, potassium ferro/ferri cyanide by employing artificially simulated bio-mimics of human sweat and saliva as unconventional electrolytes. Typically, electron transfer characteristics of the redox couple, [Fe(CN)6]3−/4− are investigated using electrochemical techniques like cyclic voltammetry and electrochemical impedance spectroscopy. Many different kinetic parameters are determined and compared with the conventional system. In addition, such electron transfer reactions have also been studied using a lyotropic liquid crystalline phase comprising of Triton X-100 and water in which the aqueous phase is replaced with either human sweat or saliva bio-mimics. From these studies, we find out the electron transfer reaction of [Fe(CN)6]3−/4− redox couple is completely diffusion controlled on both Au and Pt disc shaped electrodes in presence of sweat and saliva bio-mimic solutions. Moreover, the reaction is partially blocked by the presence of lyotropic liquid crystalline phase consisting of sweat and saliva bio-mimics indicating the predominant charge transfer controlled process for the redox probe. However, the rate constant values associated with the electron transfer reaction are drastically reduced in presence of liquid crystalline phase. These studies are essentially carried out to assess the effect of sweat and saliva on the electrochemistry of Fe2+/3+ redox couple.P. KrishnaveniV. GaneshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q P. Krishnaveni V. Ganesh Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions
description	Abstract Modern day hospital treatments aim at developing electrochemical biosensors for early diagnosis of diseases using unconventional human bio-fluids like sweat and saliva by monitoring the electron transfer reactions of target analytes. Such kinds of health care diagnostics primarily avoid the usage of human blood and urine samples. In this context, here we have investigated the electron transfer reaction of a well-known and commonly used redox probe namely, potassium ferro/ferri cyanide by employing artificially simulated bio-mimics of human sweat and saliva as unconventional electrolytes. Typically, electron transfer characteristics of the redox couple, [Fe(CN)6]3−/4− are investigated using electrochemical techniques like cyclic voltammetry and electrochemical impedance spectroscopy. Many different kinetic parameters are determined and compared with the conventional system. In addition, such electron transfer reactions have also been studied using a lyotropic liquid crystalline phase comprising of Triton X-100 and water in which the aqueous phase is replaced with either human sweat or saliva bio-mimics. From these studies, we find out the electron transfer reaction of [Fe(CN)6]3−/4− redox couple is completely diffusion controlled on both Au and Pt disc shaped electrodes in presence of sweat and saliva bio-mimic solutions. Moreover, the reaction is partially blocked by the presence of lyotropic liquid crystalline phase consisting of sweat and saliva bio-mimics indicating the predominant charge transfer controlled process for the redox probe. However, the rate constant values associated with the electron transfer reaction are drastically reduced in presence of liquid crystalline phase. These studies are essentially carried out to assess the effect of sweat and saliva on the electrochemistry of Fe2+/3+ redox couple.
format	article
author	P. Krishnaveni V. Ganesh
author_facet	P. Krishnaveni V. Ganesh
author_sort	P. Krishnaveni
title	Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions
title_short	Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions
title_full	Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions
title_fullStr	Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions
title_full_unstemmed	Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions
title_sort	electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4dee9162c4f341fdb09acd62fb598931
work_keys_str_mv	AT pkrishnaveni electrontransferstudiesofaconventionalredoxprobeinhumansweatandsalivabiomimickingconditions AT vganesh electrontransferstudiesofaconventionalredoxprobeinhumansweatandsalivabiomimickingconditions
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Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions

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