Relationships between gene expression and brain wiring in the adult rodent brain.

We studied the global relationship between gene expression and neuroanatomical connectivity in the adult rodent brain. We utilized a large data set of the rat brain "connectome" from the Brain Architecture Management System (942 brain regions and over 5000 connections) and used statistical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Leon French, Paul Pavlidis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4df209b1b447420ea7a7288f1e09533b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4df209b1b447420ea7a7288f1e09533b
record_format	dspace
spelling	oai:doaj.org-article:4df209b1b447420ea7a7288f1e09533b2021-11-18T05:50:48ZRelationships between gene expression and brain wiring in the adult rodent brain.1553-734X1553-735810.1371/journal.pcbi.1001049https://doaj.org/article/4df209b1b447420ea7a7288f1e09533b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21253556/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358We studied the global relationship between gene expression and neuroanatomical connectivity in the adult rodent brain. We utilized a large data set of the rat brain "connectome" from the Brain Architecture Management System (942 brain regions and over 5000 connections) and used statistical approaches to relate the data to the gene expression signatures of 17,530 genes in 142 anatomical regions from the Allen Brain Atlas. Our analysis shows that adult gene expression signatures have a statistically significant relationship to connectivity. In particular, brain regions that have similar expression profiles tend to have similar connectivity profiles, and this effect is not entirely attributable to spatial correlations. In addition, brain regions which are connected have more similar expression patterns. Using a simple optimization approach, we identified a set of genes most correlated with neuroanatomical connectivity, and find that this set is enriched for genes involved in neuronal development and axon guidance. A number of the genes have been implicated in neurodevelopmental disorders such as autistic spectrum disorder. Our results have the potential to shed light on the role of gene expression patterns in influencing neuronal activity and connectivity, with potential applications to our understanding of brain disorders. Supplementary data are available at http://www.chibi.ubc.ca/ABAMS.Leon FrenchPaul PavlidisPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 1, p e1001049 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Leon French Paul Pavlidis Relationships between gene expression and brain wiring in the adult rodent brain.
description	We studied the global relationship between gene expression and neuroanatomical connectivity in the adult rodent brain. We utilized a large data set of the rat brain "connectome" from the Brain Architecture Management System (942 brain regions and over 5000 connections) and used statistical approaches to relate the data to the gene expression signatures of 17,530 genes in 142 anatomical regions from the Allen Brain Atlas. Our analysis shows that adult gene expression signatures have a statistically significant relationship to connectivity. In particular, brain regions that have similar expression profiles tend to have similar connectivity profiles, and this effect is not entirely attributable to spatial correlations. In addition, brain regions which are connected have more similar expression patterns. Using a simple optimization approach, we identified a set of genes most correlated with neuroanatomical connectivity, and find that this set is enriched for genes involved in neuronal development and axon guidance. A number of the genes have been implicated in neurodevelopmental disorders such as autistic spectrum disorder. Our results have the potential to shed light on the role of gene expression patterns in influencing neuronal activity and connectivity, with potential applications to our understanding of brain disorders. Supplementary data are available at http://www.chibi.ubc.ca/ABAMS.
format	article
author	Leon French Paul Pavlidis
author_facet	Leon French Paul Pavlidis
author_sort	Leon French
title	Relationships between gene expression and brain wiring in the adult rodent brain.
title_short	Relationships between gene expression and brain wiring in the adult rodent brain.
title_full	Relationships between gene expression and brain wiring in the adult rodent brain.
title_fullStr	Relationships between gene expression and brain wiring in the adult rodent brain.
title_full_unstemmed	Relationships between gene expression and brain wiring in the adult rodent brain.
title_sort	relationships between gene expression and brain wiring in the adult rodent brain.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4df209b1b447420ea7a7288f1e09533b
work_keys_str_mv	AT leonfrench relationshipsbetweengeneexpressionandbrainwiringintheadultrodentbrain AT paulpavlidis relationshipsbetweengeneexpressionandbrainwiringintheadultrodentbrain
_version_	1718424783882813440

Relationships between gene expression and brain wiring in the adult rodent brain.

Ejemplares similares