Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Yuemei Han,1,* Xu Xu,1,* Junmei Tang,1,* Chenghui Shen,2 Quankui Lin,1,2 Hao Chen1,2 1School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, 2Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People’s Republic of China...

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Autores principales:	Han Y, Xu X, Tang J, Shen C, Lin Q, Chen H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Intraocular lens Surface modification Zwitterion PCO In vivo Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4df29ca4da114c528dfa90b6aadc0105
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spelling	oai:doaj.org-article:4df29ca4da114c528dfa90b6aadc01052021-12-02T02:32:06ZBottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility1178-2013https://doaj.org/article/4df29ca4da114c528dfa90b6aadc01052016-12-01T00:00:00Zhttps://www.dovepress.com/bottom-up-fabrication-of-zwitterionic-polymer-brushes-on-intraocular-l-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuemei Han,1,* Xu Xu,1,* Junmei Tang,1,* Chenghui Shen,2 Quankui Lin,1,2 Hao Chen1,2 1School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, 2Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Intraocular lens (IOL) is an efficient implantable device commonly used for treating cataracts. However, bioadhesion of bacteria or residual lens epithelial cells on the IOL surface after surgery causes postoperative complications, such as endophthalmitis or posterior capsular opacification, and leads to loss of sight again. In the present study, zwitterionic polymer brushes were fabricated on the IOL surface via bottom-up grafting procedure. The attenuated total reflection-Fourier transform infrared and contact angle measurements indicated successful surface modification, as well as excellent hydrophilicity. The coating of hydrophilic zwitterionic polymer effectively decreased the bioadhesion of lens epithelial cells or bacteria. In vivo intraocular implantation results showed good in vivo biocompatibility of zwitterionic IOL and its effectiveness against postoperative complications. Keywords: RAFT, surface modification, endophthalmitis, PCO, in vivoHan YXu XTang JShen CLin QChen HDove Medical PressarticleIntraocular lensSurface modificationZwitterionPCOIn vivoMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 127-135 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intraocular lens Surface modification Zwitterion PCO In vivo Medicine (General) R5-920
spellingShingle	Intraocular lens Surface modification Zwitterion PCO In vivo Medicine (General) R5-920 Han Y Xu X Tang J Shen C Lin Q Chen H Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
description	Yuemei Han,1,* Xu Xu,1,* Junmei Tang,1,* Chenghui Shen,2 Quankui Lin,1,2 Hao Chen1,2 1School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, 2Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Intraocular lens (IOL) is an efficient implantable device commonly used for treating cataracts. However, bioadhesion of bacteria or residual lens epithelial cells on the IOL surface after surgery causes postoperative complications, such as endophthalmitis or posterior capsular opacification, and leads to loss of sight again. In the present study, zwitterionic polymer brushes were fabricated on the IOL surface via bottom-up grafting procedure. The attenuated total reflection-Fourier transform infrared and contact angle measurements indicated successful surface modification, as well as excellent hydrophilicity. The coating of hydrophilic zwitterionic polymer effectively decreased the bioadhesion of lens epithelial cells or bacteria. In vivo intraocular implantation results showed good in vivo biocompatibility of zwitterionic IOL and its effectiveness against postoperative complications. Keywords: RAFT, surface modification, endophthalmitis, PCO, in vivo
format	article
author	Han Y Xu X Tang J Shen C Lin Q Chen H
author_facet	Han Y Xu X Tang J Shen C Lin Q Chen H
author_sort	Han Y
title	Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
title_short	Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
title_full	Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
title_fullStr	Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
title_full_unstemmed	Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
title_sort	bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4df29ca4da114c528dfa90b6aadc0105
work_keys_str_mv	AT hany bottomupfabricationofzwitterionicpolymerbrushesonintraocularlensforimprovedbiocompatibility AT xux bottomupfabricationofzwitterionicpolymerbrushesonintraocularlensforimprovedbiocompatibility AT tangj bottomupfabricationofzwitterionicpolymerbrushesonintraocularlensforimprovedbiocompatibility AT shenc bottomupfabricationofzwitterionicpolymerbrushesonintraocularlensforimprovedbiocompatibility AT linq bottomupfabricationofzwitterionicpolymerbrushesonintraocularlensforimprovedbiocompatibility AT chenh bottomupfabricationofzwitterionicpolymerbrushesonintraocularlensforimprovedbiocompatibility
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Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

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