Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay intermediates produced by several common decay pathway...

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Autores principales:	Volker Boehm, Jennifer V. Gerbracht, Marie-Charlotte Marx, Niels H. Gehring
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4df3f5547cd041fa9a60258e7949e822
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spelling	oai:doaj.org-article:4df3f5547cd041fa9a60258e7949e8222021-12-02T14:40:14ZInterrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences10.1038/ncomms136912041-1723https://doaj.org/article/4df3f5547cd041fa9a60258e7949e8222016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13691https://doaj.org/toc/2041-1723Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay intermediates produced by several common decay pathways.Volker BoehmJennifer V. GerbrachtMarie-Charlotte MarxNiels H. GehringNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Volker Boehm Jennifer V. Gerbracht Marie-Charlotte Marx Niels H. Gehring Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences
description	Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay intermediates produced by several common decay pathways.
format	article
author	Volker Boehm Jennifer V. Gerbracht Marie-Charlotte Marx Niels H. Gehring
author_facet	Volker Boehm Jennifer V. Gerbracht Marie-Charlotte Marx Niels H. Gehring
author_sort	Volker Boehm
title	Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences
title_short	Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences
title_full	Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences
title_fullStr	Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences
title_full_unstemmed	Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences
title_sort	interrogating the degradation pathways of unstable mrnas with xrn1-resistant sequences
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4df3f5547cd041fa9a60258e7949e822
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Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

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