ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

The regulation of PD-L1 via proteasomal degradation is unclear. Here, the authors show that EGFR inhibition activates GSK3 α to promote PD-L1 phosphorylation, which leads to PD-L1 ubiquitination and proteasome mediated degradation by ARIH1 E3 ligase.

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Autores principales:	Youqian Wu, Chao Zhang, Xiaolan Liu, Zhengfu He, Bing Shan, Qingxin Zeng, Qingwei Zhao, Huaying Zhu, Hongwei Liao, Xufeng Cen, Xiaoyan Xu, Mengmeng Zhang, Tingjun Hou, Zhe Wang, Huanhuan Yan, Shuying Yang, Yaqin Sun, Yanying Chen, Ronghai Wu, Tingxue Xie, Wei Chen, Ayaz Najafov, Songmin Ying, Hongguang Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4df5793a5b60480c842c52657fc986f7
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spelling	oai:doaj.org-article:4df5793a5b60480c842c52657fc986f72021-12-02T16:45:05ZARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation10.1038/s41467-021-22467-82041-1723https://doaj.org/article/4df5793a5b60480c842c52657fc986f72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22467-8https://doaj.org/toc/2041-1723The regulation of PD-L1 via proteasomal degradation is unclear. Here, the authors show that EGFR inhibition activates GSK3 α to promote PD-L1 phosphorylation, which leads to PD-L1 ubiquitination and proteasome mediated degradation by ARIH1 E3 ligase.Youqian WuChao ZhangXiaolan LiuZhengfu HeBing ShanQingxin ZengQingwei ZhaoHuaying ZhuHongwei LiaoXufeng CenXiaoyan XuMengmeng ZhangTingjun HouZhe WangHuanhuan YanShuying YangYaqin SunYanying ChenRonghai WuTingxue XieWei ChenAyaz NajafovSongmin YingHongguang XiaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Youqian Wu Chao Zhang Xiaolan Liu Zhengfu He Bing Shan Qingxin Zeng Qingwei Zhao Huaying Zhu Hongwei Liao Xufeng Cen Xiaoyan Xu Mengmeng Zhang Tingjun Hou Zhe Wang Huanhuan Yan Shuying Yang Yaqin Sun Yanying Chen Ronghai Wu Tingxue Xie Wei Chen Ayaz Najafov Songmin Ying Hongguang Xia ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
description	The regulation of PD-L1 via proteasomal degradation is unclear. Here, the authors show that EGFR inhibition activates GSK3 α to promote PD-L1 phosphorylation, which leads to PD-L1 ubiquitination and proteasome mediated degradation by ARIH1 E3 ligase.
format	article
author	Youqian Wu Chao Zhang Xiaolan Liu Zhengfu He Bing Shan Qingxin Zeng Qingwei Zhao Huaying Zhu Hongwei Liao Xufeng Cen Xiaoyan Xu Mengmeng Zhang Tingjun Hou Zhe Wang Huanhuan Yan Shuying Yang Yaqin Sun Yanying Chen Ronghai Wu Tingxue Xie Wei Chen Ayaz Najafov Songmin Ying Hongguang Xia
author_facet	Youqian Wu Chao Zhang Xiaolan Liu Zhengfu He Bing Shan Qingxin Zeng Qingwei Zhao Huaying Zhu Hongwei Liao Xufeng Cen Xiaoyan Xu Mengmeng Zhang Tingjun Hou Zhe Wang Huanhuan Yan Shuying Yang Yaqin Sun Yanying Chen Ronghai Wu Tingxue Xie Wei Chen Ayaz Najafov Songmin Ying Hongguang Xia
author_sort	Youqian Wu
title	ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
title_short	ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
title_full	ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
title_fullStr	ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
title_full_unstemmed	ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
title_sort	arih1 signaling promotes anti-tumor immunity by targeting pd-l1 for proteasomal degradation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4df5793a5b60480c842c52657fc986f7
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ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

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