Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection

Abstract Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the underlying role of metabolism in delirium-...

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Autores principales:	Miroslava Cuperlovic-Culf, Emma L. Cunningham, Hossen Teimoorinia, Anuradha Surendra, Xiaobei Pan, Steffany A. L. Bennett, Mijin Jung, Bernadette McGuiness, Anthony Peter Passmore, David Beverland, Brian D. Green
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4df6d3296fd944089207c388aeb2a432
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spelling	oai:doaj.org-article:4df6d3296fd944089207c388aeb2a4322021-12-02T14:59:09ZMetabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection10.1038/s41598-021-90243-12045-2322https://doaj.org/article/4df6d3296fd944089207c388aeb2a4322021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90243-1https://doaj.org/toc/2045-2322Abstract Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the underlying role of metabolism in delirium-susceptibility in the postoperative setting using metabolomic profiling of cerebrospinal fluid and blood taken from the same patients prior to planned orthopaedic surgery. Distance correlation analysis and Random Forest (RF) feature selection were used to determine changes in metabolic networks. We found significant concentration differences in several amino acids, acylcarnitines and polyamines linking delirium-prone patients to known factors in Alzheimer’s disease such as monoamine oxidase B (MAOB) protein. Subsequent computational structural comparison between MAOB and angiotensin converting enzyme 2 as well as protein–protein docking analysis showed that there potentially is strong binding of SARS-CoV-2 spike protein to MAOB. The possibility that SARS-CoV-2 influences MAOB activity leading to the observed neurological and platelet-based complications of SARS-CoV-2 infection requires further investigation.Miroslava Cuperlovic-CulfEmma L. CunninghamHossen TeimooriniaAnuradha SurendraXiaobei PanSteffany A. L. BennettMijin JungBernadette McGuinessAnthony Peter PassmoreDavid BeverlandBrian D. GreenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miroslava Cuperlovic-Culf Emma L. Cunningham Hossen Teimoorinia Anuradha Surendra Xiaobei Pan Steffany A. L. Bennett Mijin Jung Bernadette McGuiness Anthony Peter Passmore David Beverland Brian D. Green Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection
description	Abstract Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the underlying role of metabolism in delirium-susceptibility in the postoperative setting using metabolomic profiling of cerebrospinal fluid and blood taken from the same patients prior to planned orthopaedic surgery. Distance correlation analysis and Random Forest (RF) feature selection were used to determine changes in metabolic networks. We found significant concentration differences in several amino acids, acylcarnitines and polyamines linking delirium-prone patients to known factors in Alzheimer’s disease such as monoamine oxidase B (MAOB) protein. Subsequent computational structural comparison between MAOB and angiotensin converting enzyme 2 as well as protein–protein docking analysis showed that there potentially is strong binding of SARS-CoV-2 spike protein to MAOB. The possibility that SARS-CoV-2 influences MAOB activity leading to the observed neurological and platelet-based complications of SARS-CoV-2 infection requires further investigation.
format	article
author	Miroslava Cuperlovic-Culf Emma L. Cunningham Hossen Teimoorinia Anuradha Surendra Xiaobei Pan Steffany A. L. Bennett Mijin Jung Bernadette McGuiness Anthony Peter Passmore David Beverland Brian D. Green
author_facet	Miroslava Cuperlovic-Culf Emma L. Cunningham Hossen Teimoorinia Anuradha Surendra Xiaobei Pan Steffany A. L. Bennett Mijin Jung Bernadette McGuiness Anthony Peter Passmore David Beverland Brian D. Green
author_sort	Miroslava Cuperlovic-Culf
title	Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection
title_short	Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection
title_full	Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection
title_fullStr	Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection
title_full_unstemmed	Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection
title_sort	metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and sars-cov-2 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4df6d3296fd944089207c388aeb2a432
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Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection

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