NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C

The study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of the NLRP3 inflammasome, caspase-1 (CASP-1), and interleukin-18 (IL-18) and at evaluating whether the increased local inflammatory reaction with clinical perio...

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Autores principales:	Petra Surlin, Luminita Lazar, Cerasella Sincar, Dorin Nicolae Gheorghe, Dora Maria Popescu, Virgil Mihail Boldeanu, Allma Pitru, Cristina Florescu, Ion Rogoveanu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/4df7184ea2db4fe7a226bbbb0784db99
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spelling	oai:doaj.org-article:4df7184ea2db4fe7a226bbbb0784db992021-11-29T00:56:15ZNLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C1466-186110.1155/2021/6917919https://doaj.org/article/4df7184ea2db4fe7a226bbbb0784db992021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6917919https://doaj.org/toc/1466-1861The study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of the NLRP3 inflammasome, caspase-1 (CASP-1), and interleukin-18 (IL-18) and at evaluating whether the increased local inflammatory reaction with clinical periodontal consequences is correlated to their upregulation. Patients were divided into four groups, according to their periodontal status and previously diagnosed hepatitis C, as follows: (i) CHC group, chronic hepatitis C patients; (ii) P group, periodontal disease patients, systemically healthy; (iii) CHC + P group, patients suffering from both conditions; and (iv) H group, systemically and periodontally healthy controls. Gingival crevicular samples were collected for quantitative analysis of the NLRP3 inflammasome, CASP-1, and IL-18. CHC + P patients expressed the worse periodontal status and the highest NLRP3, CASP-1, and IL-18 levels, the difference being statistically significant (p<0.05). The P group patients also expressed significantly more elevated NLRP3, CASP-1, and IL-18 levels, as compared to nonperiodontal patients (CHC and H groups). Chronic hepatitis C and periodontal disease could have a significant influence on the upregulation of NLRP3 inflammasome and its components, possibly contributing to an increased local inflammatory reaction and clinical periodontal consequences.Petra SurlinLuminita LazarCerasella SincarDorin Nicolae GheorgheDora Maria PopescuVirgil Mihail BoldeanuAllma PitruCristina FlorescuIon RogoveanuHindawi LimitedarticlePathologyRB1-214ENMediators of Inflammation, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Petra Surlin Luminita Lazar Cerasella Sincar Dorin Nicolae Gheorghe Dora Maria Popescu Virgil Mihail Boldeanu Allma Pitru Cristina Florescu Ion Rogoveanu NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C
description	The study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of the NLRP3 inflammasome, caspase-1 (CASP-1), and interleukin-18 (IL-18) and at evaluating whether the increased local inflammatory reaction with clinical periodontal consequences is correlated to their upregulation. Patients were divided into four groups, according to their periodontal status and previously diagnosed hepatitis C, as follows: (i) CHC group, chronic hepatitis C patients; (ii) P group, periodontal disease patients, systemically healthy; (iii) CHC + P group, patients suffering from both conditions; and (iv) H group, systemically and periodontally healthy controls. Gingival crevicular samples were collected for quantitative analysis of the NLRP3 inflammasome, CASP-1, and IL-18. CHC + P patients expressed the worse periodontal status and the highest NLRP3, CASP-1, and IL-18 levels, the difference being statistically significant (p<0.05). The P group patients also expressed significantly more elevated NLRP3, CASP-1, and IL-18 levels, as compared to nonperiodontal patients (CHC and H groups). Chronic hepatitis C and periodontal disease could have a significant influence on the upregulation of NLRP3 inflammasome and its components, possibly contributing to an increased local inflammatory reaction and clinical periodontal consequences.
format	article
author	Petra Surlin Luminita Lazar Cerasella Sincar Dorin Nicolae Gheorghe Dora Maria Popescu Virgil Mihail Boldeanu Allma Pitru Cristina Florescu Ion Rogoveanu
author_facet	Petra Surlin Luminita Lazar Cerasella Sincar Dorin Nicolae Gheorghe Dora Maria Popescu Virgil Mihail Boldeanu Allma Pitru Cristina Florescu Ion Rogoveanu
author_sort	Petra Surlin
title	NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C
title_short	NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C
title_full	NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C
title_fullStr	NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C
title_full_unstemmed	NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C
title_sort	nlrp3 inflammasome expression in gingival crevicular fluid of patients with periodontitis and chronic hepatitis c
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/4df7184ea2db4fe7a226bbbb0784db99
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NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C

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