Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.
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Nature Portfolio
2016
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oai:doaj.org-article:4df7cfd06ae5433d88273671aa9365b62021-12-02T17:33:07ZCutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors10.1038/ncomms123482041-1723https://doaj.org/article/4df7cfd06ae5433d88273671aa9365b62016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12348https://doaj.org/toc/2041-1723BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.Helena Escuin-OrdinasShuoran LiMichael W. XieLu SunWilly HugoRong Rong HuangJing JiaoFelipe Meira de-FariaSusan RealegenoPaige KrystofinskiAriel AzhdamSara Marie D. KomenanMohammad AtefiBegoña Comin-AnduixMatteo PellegriniAlistair J. CochranRobert L. ModlinHarvey R. HerschmanRoger S. LoWilliam H. McBrideTatiana SeguraAntoni RibasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Helena Escuin-Ordinas Shuoran Li Michael W. Xie Lu Sun Willy Hugo Rong Rong Huang Jing Jiao Felipe Meira de-Faria Susan Realegeno Paige Krystofinski Ariel Azhdam Sara Marie D. Komenan Mohammad Atefi Begoña Comin-Anduix Matteo Pellegrini Alistair J. Cochran Robert L. Modlin Harvey R. Herschman Roger S. Lo William H. McBride Tatiana Segura Antoni Ribas Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| description |
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes. |
| format |
article |
| author |
Helena Escuin-Ordinas Shuoran Li Michael W. Xie Lu Sun Willy Hugo Rong Rong Huang Jing Jiao Felipe Meira de-Faria Susan Realegeno Paige Krystofinski Ariel Azhdam Sara Marie D. Komenan Mohammad Atefi Begoña Comin-Anduix Matteo Pellegrini Alistair J. Cochran Robert L. Modlin Harvey R. Herschman Roger S. Lo William H. McBride Tatiana Segura Antoni Ribas |
| author_facet |
Helena Escuin-Ordinas Shuoran Li Michael W. Xie Lu Sun Willy Hugo Rong Rong Huang Jing Jiao Felipe Meira de-Faria Susan Realegeno Paige Krystofinski Ariel Azhdam Sara Marie D. Komenan Mohammad Atefi Begoña Comin-Anduix Matteo Pellegrini Alistair J. Cochran Robert L. Modlin Harvey R. Herschman Roger S. Lo William H. McBride Tatiana Segura Antoni Ribas |
| author_sort |
Helena Escuin-Ordinas |
| title |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_short |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_full |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_fullStr |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_full_unstemmed |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_sort |
cutaneous wound healing through paradoxical mapk activation by braf inhibitors |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/4df7cfd06ae5433d88273671aa9365b6 |
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