Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

CRISPR-Cas9 has been utilized to screen the genome in loss-of-function studies to identify genetic interactions. Here the authors compare catalytically active and dead Cas9 and observe different off-target effects in a screen for essential genes.

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Detalles Bibliográficos
Autores principales: Joseph Rosenbluh, Han Xu, William Harrington, Stanley Gill, Xiaoxing Wang, Francisca Vazquez, David E. Root, Aviad Tsherniak, William C. Hahn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4df7e335ce2740e5852e4891179365f8
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