Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes

Abstract The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographic...

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Autores principales:	Yong Song, Michelle J. Schwager, Vibeke Backer, Jing Guo, Celeste Porsbjerg, Siew-Kim Khoo, Ingrid A. Laing, Eric K. Moses, Peter LeSouëf, Guicheng (Brad) Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4df8280c1da84ecdb038918a3168727a
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spelling	oai:doaj.org-article:4df8280c1da84ecdb038918a3168727a2021-12-02T16:06:01ZEnvironment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes10.1038/s41598-017-06791-y2045-2322https://doaj.org/article/4df8280c1da84ecdb038918a3168727a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06791-yhttps://doaj.org/toc/2045-2322Abstract The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit residing either in the westernized environment of Denmark or in the rural area of Greenland. Our results showed that lung function was associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence. LT-α SNP rs909253 and rs1041981 were significantly associated with bronchitis risk. LT-α SNP rs2844484 was related to dermatitis susceptibility and was significantly influenced by the place of residence. The observed gene-phenotype relationships were exclusively present in one population and absent in the other population. We conclude that the genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases.Yong SongMichelle J. SchwagerVibeke BackerJing GuoCeleste PorsbjergSiew-Kim KhooIngrid A. LaingEric K. MosesPeter LeSouëfGuicheng (Brad) ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Song Michelle J. Schwager Vibeke Backer Jing Guo Celeste Porsbjerg Siew-Kim Khoo Ingrid A. Laing Eric K. Moses Peter LeSouëf Guicheng (Brad) Zhang Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes
description	Abstract The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit residing either in the westernized environment of Denmark or in the rural area of Greenland. Our results showed that lung function was associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence. LT-α SNP rs909253 and rs1041981 were significantly associated with bronchitis risk. LT-α SNP rs2844484 was related to dermatitis susceptibility and was significantly influenced by the place of residence. The observed gene-phenotype relationships were exclusively present in one population and absent in the other population. We conclude that the genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases.
format	article
author	Yong Song Michelle J. Schwager Vibeke Backer Jing Guo Celeste Porsbjerg Siew-Kim Khoo Ingrid A. Laing Eric K. Moses Peter LeSouëf Guicheng (Brad) Zhang
author_facet	Yong Song Michelle J. Schwager Vibeke Backer Jing Guo Celeste Porsbjerg Siew-Kim Khoo Ingrid A. Laing Eric K. Moses Peter LeSouëf Guicheng (Brad) Zhang
author_sort	Yong Song
title	Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes
title_short	Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes
title_full	Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes
title_fullStr	Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes
title_full_unstemmed	Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes
title_sort	environment changes genetic effects on respiratory conditions and allergic phenotypes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4df8280c1da84ecdb038918a3168727a
work_keys_str_mv	AT yongsong environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT michellejschwager environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT vibekebacker environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT jingguo environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT celesteporsbjerg environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT siewkimkhoo environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT ingridalaing environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT erickmoses environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT peterlesouef environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes AT guichengbradzhang environmentchangesgeneticeffectsonrespiratoryconditionsandallergicphenotypes
_version_	1718385145502760960

Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes

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