Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats

Abstract Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the present study we investigated the effects of dietary...

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Autores principales:	Maria M. Glavas, Queenie Hui, Ian Miao, Fan Yang, Suheda Erener, Kacey J. Prentice, Michael B. Wheeler, Timothy J. Kieffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4dfa192eb736486bb29246613caa1b5a
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spelling	oai:doaj.org-article:4dfa192eb736486bb29246613caa1b5a2021-12-02T15:40:00ZEarly overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats10.1038/s41598-021-93409-z2045-2322https://doaj.org/article/4dfa192eb736486bb29246613caa1b5a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93409-zhttps://doaj.org/toc/2045-2322Abstract Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the present study we investigated the effects of dietary fat composition on early overnutrition-induced body weight and glucose regulation in Swiss Webster mice, which show susceptibility to high-fat diet-induced diabetes. We compared glucose homeostasis between a high-fat lard-based (HFL) diet, high in saturated fats, and a high-fat olive oil/fish oil-based (HFO) diet, high in monounsaturated and omega-3 fats. We hypothesized that the healthier fat profile of the latter diet would improve early overnutrition-induced glucose dysregulation. However, early overnutrition HFO pups gained more weight and adiposity and had higher diabetes incidence compared to HFL. In contrast, control pups had less weight gain, adiposity, and lower diabetes incidence. Plasma metabolomics revealed reductions in various phosphatidylcholine species in early overnutrition HFO mice as well as with diabetes. These findings suggest that early overnutrition may negate any beneficial effects of a high-fat diet that favours monounsaturated and omega-3 fats over saturated fats. Thus, quantity, quality, and timing of fat intake throughout life should be considered with respect to metabolic health outcomes.Maria M. GlavasQueenie HuiIan MiaoFan YangSuheda ErenerKacey J. PrenticeMichael B. WheelerTimothy J. KiefferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria M. Glavas Queenie Hui Ian Miao Fan Yang Suheda Erener Kacey J. Prentice Michael B. Wheeler Timothy J. Kieffer Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
description	Abstract Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the present study we investigated the effects of dietary fat composition on early overnutrition-induced body weight and glucose regulation in Swiss Webster mice, which show susceptibility to high-fat diet-induced diabetes. We compared glucose homeostasis between a high-fat lard-based (HFL) diet, high in saturated fats, and a high-fat olive oil/fish oil-based (HFO) diet, high in monounsaturated and omega-3 fats. We hypothesized that the healthier fat profile of the latter diet would improve early overnutrition-induced glucose dysregulation. However, early overnutrition HFO pups gained more weight and adiposity and had higher diabetes incidence compared to HFL. In contrast, control pups had less weight gain, adiposity, and lower diabetes incidence. Plasma metabolomics revealed reductions in various phosphatidylcholine species in early overnutrition HFO mice as well as with diabetes. These findings suggest that early overnutrition may negate any beneficial effects of a high-fat diet that favours monounsaturated and omega-3 fats over saturated fats. Thus, quantity, quality, and timing of fat intake throughout life should be considered with respect to metabolic health outcomes.
format	article
author	Maria M. Glavas Queenie Hui Ian Miao Fan Yang Suheda Erener Kacey J. Prentice Michael B. Wheeler Timothy J. Kieffer
author_facet	Maria M. Glavas Queenie Hui Ian Miao Fan Yang Suheda Erener Kacey J. Prentice Michael B. Wheeler Timothy J. Kieffer
author_sort	Maria M. Glavas
title	Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
title_short	Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
title_full	Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
title_fullStr	Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
title_full_unstemmed	Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
title_sort	early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4dfa192eb736486bb29246613caa1b5a
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Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats

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