Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding...

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Bibliographic Details
Main Authors: Gregory J. Fonseca, Jenhan Tao, Emma M. Westin, Sascha H. Duttke, Nathanael J. Spann, Tobias Strid, Zeyang Shen, Joshua D. Stender, Mashito Sakai, Verena M. Link, Christopher Benner, Christopher K. Glass
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/4dfc6b7b8a3849c7bce7ab3e8395079f
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Summary:Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.

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