Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gregory J. Fonseca, Jenhan Tao, Emma M. Westin, Sascha H. Duttke, Nathanael J. Spann, Tobias Strid, Zeyang Shen, Joshua D. Stender, Mashito Sakai, Verena M. Link, Christopher Benner, Christopher K. Glass
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dfc6b7b8a3849c7bce7ab3e8395079f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4dfc6b7b8a3849c7bce7ab3e8395079f
record_format	dspace
spelling	oai:doaj.org-article:4dfc6b7b8a3849c7bce7ab3e8395079f2021-12-02T17:01:27ZDiverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages10.1038/s41467-018-08236-02041-1723https://doaj.org/article/4dfc6b7b8a3849c7bce7ab3e8395079f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08236-0https://doaj.org/toc/2041-1723Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.Gregory J. FonsecaJenhan TaoEmma M. WestinSascha H. DuttkeNathanael J. SpannTobias StridZeyang ShenJoshua D. StenderMashito SakaiVerena M. LinkChristopher BennerChristopher K. GlassNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gregory J. Fonseca Jenhan Tao Emma M. Westin Sascha H. Duttke Nathanael J. Spann Tobias Strid Zeyang Shen Joshua D. Stender Mashito Sakai Verena M. Link Christopher Benner Christopher K. Glass Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
description	Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.
format	article
author	Gregory J. Fonseca Jenhan Tao Emma M. Westin Sascha H. Duttke Nathanael J. Spann Tobias Strid Zeyang Shen Joshua D. Stender Mashito Sakai Verena M. Link Christopher Benner Christopher K. Glass
author_facet	Gregory J. Fonseca Jenhan Tao Emma M. Westin Sascha H. Duttke Nathanael J. Spann Tobias Strid Zeyang Shen Joshua D. Stender Mashito Sakai Verena M. Link Christopher Benner Christopher K. Glass
author_sort	Gregory J. Fonseca
title	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_short	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_full	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_fullStr	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_full_unstemmed	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
title_sort	diverse motif ensembles specify non-redundant dna binding activities of ap-1 family members in macrophages
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4dfc6b7b8a3849c7bce7ab3e8395079f
work_keys_str_mv	AT gregoryjfonseca diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT jenhantao diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT emmamwestin diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT saschahduttke diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT nathanaeljspann diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT tobiasstrid diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT zeyangshen diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT joshuadstender diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT mashitosakai diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT verenamlink diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT christopherbenner diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages AT christopherkglass diversemotifensemblesspecifynonredundantdnabindingactivitiesofap1familymembersinmacrophages
_version_	1718382145287749632

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Ejemplares similares