A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the...

Full description

Saved in:
Bibliographic Details
Main Authors: Luca Fagnocchi, Alessandro Cherubini, Hiroshi Hatsuda, Alessandra Fasciani, Stefania Mazzoleni, Vittoria Poli, Valeria Berno, Riccardo L. Rossi, Rolland Reinbold, Max Endele, Timm Schroeder, Marina Rocchigiani, Żaneta Szkarłat, Salvatore Oliviero, Stephen Dalton, Alessio Zippo
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/4dfc9facb00e4f1c81f05614a3a4b0b2
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway.

Similar Items