A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the...

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Autores principales: Luca Fagnocchi, Alessandro Cherubini, Hiroshi Hatsuda, Alessandra Fasciani, Stefania Mazzoleni, Vittoria Poli, Valeria Berno, Riccardo L. Rossi, Rolland Reinbold, Max Endele, Timm Schroeder, Marina Rocchigiani, Żaneta Szkarłat, Salvatore Oliviero, Stephen Dalton, Alessio Zippo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4dfc9facb00e4f1c81f05614a3a4b0b2
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Sumario:The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway.

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