A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the...

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Autores principales:	Luca Fagnocchi, Alessandro Cherubini, Hiroshi Hatsuda, Alessandra Fasciani, Stefania Mazzoleni, Vittoria Poli, Valeria Berno, Riccardo L. Rossi, Rolland Reinbold, Max Endele, Timm Schroeder, Marina Rocchigiani, Żaneta Szkarłat, Salvatore Oliviero, Stephen Dalton, Alessio Zippo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dfc9facb00e4f1c81f05614a3a4b0b2
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spelling	oai:doaj.org-article:4dfc9facb00e4f1c81f05614a3a4b0b22021-12-02T16:58:00ZA Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity10.1038/ncomms119032041-1723https://doaj.org/article/4dfc9facb00e4f1c81f05614a3a4b0b22016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11903https://doaj.org/toc/2041-1723The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway.Luca FagnocchiAlessandro CherubiniHiroshi HatsudaAlessandra FascianiStefania MazzoleniVittoria PoliValeria BernoRiccardo L. RossiRolland ReinboldMax EndeleTimm SchroederMarina RocchigianiŻaneta SzkarłatSalvatore OlivieroStephen DaltonAlessio ZippoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luca Fagnocchi Alessandro Cherubini Hiroshi Hatsuda Alessandra Fasciani Stefania Mazzoleni Vittoria Poli Valeria Berno Riccardo L. Rossi Rolland Reinbold Max Endele Timm Schroeder Marina Rocchigiani Żaneta Szkarłat Salvatore Oliviero Stephen Dalton Alessio Zippo A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
description	The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway.
format	article
author	Luca Fagnocchi Alessandro Cherubini Hiroshi Hatsuda Alessandra Fasciani Stefania Mazzoleni Vittoria Poli Valeria Berno Riccardo L. Rossi Rolland Reinbold Max Endele Timm Schroeder Marina Rocchigiani Żaneta Szkarłat Salvatore Oliviero Stephen Dalton Alessio Zippo
author_facet	Luca Fagnocchi Alessandro Cherubini Hiroshi Hatsuda Alessandra Fasciani Stefania Mazzoleni Vittoria Poli Valeria Berno Riccardo L. Rossi Rolland Reinbold Max Endele Timm Schroeder Marina Rocchigiani Żaneta Szkarłat Salvatore Oliviero Stephen Dalton Alessio Zippo
author_sort	Luca Fagnocchi
title	A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
title_short	A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
title_full	A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
title_fullStr	A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
title_full_unstemmed	A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
title_sort	myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4dfc9facb00e4f1c81f05614a3a4b0b2
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A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

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