Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration.
Fragile X associated tremor/ataxia syndrome (FXTAS) is a late onset neurodegenerative disorder caused by aberrant expansion of CGG repeats in 5' UTR of FMR1 gene. The elevated mRNA confers a toxic gain-of-function thought to be the critical event of pathogenesis. Expressing rCGG90 repeats of th...
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Autores principales: | Yunting Lin, Chengyuan Tang, Hua He, Ranhui Duan |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/4dfd52dca8224e3f97f135e2a7943068 |
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