Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration.

Fragile X associated tremor/ataxia syndrome (FXTAS) is a late onset neurodegenerative disorder caused by aberrant expansion of CGG repeats in 5' UTR of FMR1 gene. The elevated mRNA confers a toxic gain-of-function thought to be the critical event of pathogenesis. Expressing rCGG90 repeats of th...

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Autores principales: Yunting Lin, Chengyuan Tang, Hua He, Ranhui Duan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/4dfd52dca8224e3f97f135e2a7943068
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