Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients

Background: The constantly increasing incidence of stroke in younger individuals substantiates an urgent need for research to elucidate underlying risk factors and etiologies. Heretofore, the vast majority of studies on stroke in the young have been carried out in European and North American regions...

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Autores principales:	Marwa Ahmed Eltemamy, Arturo Tamayo, Eyad Altarsha, Annahita Sedghi, Lars-Peder Pallesen, Jessica Barlinn, Volker Puetz, Ben Min-Woo Illigens, Kristian Barlinn, Timo Siepmann
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	stroke ischemic stroke stroke in young Saudi Arabia risk factors juvenile Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4e023659827e4186b2272652d098bd25
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spelling	oai:doaj.org-article:4e023659827e4186b2272652d098bd252021-11-12T05:04:49ZCerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients1664-229510.3389/fneur.2021.736818https://doaj.org/article/4e023659827e4186b2272652d098bd252021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.736818/fullhttps://doaj.org/toc/1664-2295Background: The constantly increasing incidence of stroke in younger individuals substantiates an urgent need for research to elucidate underlying risk factors and etiologies. Heretofore, the vast majority of studies on stroke in the young have been carried out in European and North American regions. We aimed to characterize cerebrovascular risk profiles in a Saudi Arabic cohort of consecutive young stroke patients.Methods: We retrospectively analyzed data from consecutive ischemic stroke patients aged 15 to 49 years who underwent detailed cardiocerebrovascular evaluation at a tertiary stroke care center in Makkah, Saudi Arabia. Distributions of risk factors and stroke etiologies were assessed in the entire cohort and in two strata of very young (15–40 years) and young to middle-aged patients (41–49) to account for variability in suggested age cutoffs.Results: In the entire cohort [n = 63, ages 44 (34–47) median, interquartile range], dyslipidemia (71.4%) and small vessel occlusion (31.7%) displayed highest prevalence followed by diabetes (52.4%) and cardioembolism (19%). In very young patients, cardioembolism was the most prevalent etiology (27.3%). Risk profiles were similar between both age strata except for a higher prevalence of diabetes among the older cohort (31.8 vs. 63.4%, p = 0.01). Logistic regression identified diabetes as strongest predictor for association to the older strata (odds ratio = 4.2, 95% confidence interval = 1.2–14.1, p = 0.02).Conclusion: Cerebrovascular risk profiles and stroke etiologies in our cohort of young stroke patients differ from those of previous cohorts, suggesting the need for tailored prevention strategies that take into account local epidemiological data on cerebrovascular health.Marwa Ahmed EltemamyMarwa Ahmed EltemamyMarwa Ahmed EltemamyArturo TamayoArturo TamayoEyad AltarshaAnnahita SedghiLars-Peder PallesenJessica BarlinnVolker PuetzBen Min-Woo IlligensKristian BarlinnTimo SiepmannFrontiers Media S.A.articlestrokeischemic strokestroke in youngSaudi Arabiarisk factorsjuvenileNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke ischemic stroke stroke in young Saudi Arabia risk factors juvenile Neurology. Diseases of the nervous system RC346-429
spellingShingle	stroke ischemic stroke stroke in young Saudi Arabia risk factors juvenile Neurology. Diseases of the nervous system RC346-429 Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Arturo Tamayo Arturo Tamayo Eyad Altarsha Annahita Sedghi Lars-Peder Pallesen Jessica Barlinn Volker Puetz Ben Min-Woo Illigens Kristian Barlinn Timo Siepmann Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients
description	Background: The constantly increasing incidence of stroke in younger individuals substantiates an urgent need for research to elucidate underlying risk factors and etiologies. Heretofore, the vast majority of studies on stroke in the young have been carried out in European and North American regions. We aimed to characterize cerebrovascular risk profiles in a Saudi Arabic cohort of consecutive young stroke patients.Methods: We retrospectively analyzed data from consecutive ischemic stroke patients aged 15 to 49 years who underwent detailed cardiocerebrovascular evaluation at a tertiary stroke care center in Makkah, Saudi Arabia. Distributions of risk factors and stroke etiologies were assessed in the entire cohort and in two strata of very young (15–40 years) and young to middle-aged patients (41–49) to account for variability in suggested age cutoffs.Results: In the entire cohort [n = 63, ages 44 (34–47) median, interquartile range], dyslipidemia (71.4%) and small vessel occlusion (31.7%) displayed highest prevalence followed by diabetes (52.4%) and cardioembolism (19%). In very young patients, cardioembolism was the most prevalent etiology (27.3%). Risk profiles were similar between both age strata except for a higher prevalence of diabetes among the older cohort (31.8 vs. 63.4%, p = 0.01). Logistic regression identified diabetes as strongest predictor for association to the older strata (odds ratio = 4.2, 95% confidence interval = 1.2–14.1, p = 0.02).Conclusion: Cerebrovascular risk profiles and stroke etiologies in our cohort of young stroke patients differ from those of previous cohorts, suggesting the need for tailored prevention strategies that take into account local epidemiological data on cerebrovascular health.
format	article
author	Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Arturo Tamayo Arturo Tamayo Eyad Altarsha Annahita Sedghi Lars-Peder Pallesen Jessica Barlinn Volker Puetz Ben Min-Woo Illigens Kristian Barlinn Timo Siepmann
author_facet	Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Arturo Tamayo Arturo Tamayo Eyad Altarsha Annahita Sedghi Lars-Peder Pallesen Jessica Barlinn Volker Puetz Ben Min-Woo Illigens Kristian Barlinn Timo Siepmann
author_sort	Marwa Ahmed Eltemamy
title	Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients
title_short	Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients
title_full	Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients
title_fullStr	Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients
title_full_unstemmed	Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients
title_sort	cerebrovascular risk profiles in a saudi arabian cohort of young stroke patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4e023659827e4186b2272652d098bd25
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Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients

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