Phage Resistance in Multidrug-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption

ABSTRACT The evolution of phage resistance poses an inevitable threat to the efficacy of phage therapy. The strategic selection of phage combinations that impose high genetic barriers to resistance and/or high compensatory fitness costs may mitigate this threat. However, for such a strategy to be ef...

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Autores principales: Shayla Hesse, Manoj Rajaure, Erin Wall, Joy Johnson, Valery Bliskovsky, Susan Gottesman, Sankar Adhya
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
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Acceso en línea:https://doaj.org/article/4e041000c950464486454e9b28544844
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