A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?

<h4>Background</h4>We used fMRI to examine functional brain abnormalities of German-speaking dyslexics who suffer from slow effortful reading but not from a reading accuracy problem. Similar to acquired cases of letter-by-letter reading, the developmental cases exhibited an abnormal stro...

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Autores principales:	Fabio Richlan, Denise Sturm, Matthias Schurz, Martin Kronbichler, Gunther Ladurner, Heinz Wimmer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e06621c79e146de9102f5028d4c6b66
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spelling	oai:doaj.org-article:4e06621c79e146de9102f5028d4c6b662021-12-02T20:11:51ZA common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?1932-620310.1371/journal.pone.0012073https://doaj.org/article/4e06621c79e146de9102f5028d4c6b662010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20711448/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We used fMRI to examine functional brain abnormalities of German-speaking dyslexics who suffer from slow effortful reading but not from a reading accuracy problem. Similar to acquired cases of letter-by-letter reading, the developmental cases exhibited an abnormal strong effect of length (i.e., number of letters) on response time for words and pseudowords.<h4>Results</h4>Corresponding to lesions of left occipito-temporal (OT) regions in acquired cases, we found a dysfunction of this region in our developmental cases who failed to exhibit responsiveness of left OT regions to the length of words and pseudowords. This abnormality in the left OT cortex was accompanied by absent responsiveness to increased sublexical reading demands in phonological inferior frontal gyrus (IFG) regions. Interestingly, there was no abnormality in the left superior temporal cortex which--corresponding to the onological deficit explanation--is considered to be the prime locus of the reading difficulties of developmental dyslexia cases.<h4>Conclusions</h4>The present functional imaging results suggest that developmental dyslexia similar to acquired letter-by-letter reading is due to a primary dysfunction of left OT regions.Fabio RichlanDenise SturmMatthias SchurzMartin KronbichlerGunther LadurnerHeinz WimmerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12073 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabio Richlan Denise Sturm Matthias Schurz Martin Kronbichler Gunther Ladurner Heinz Wimmer A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
description	<h4>Background</h4>We used fMRI to examine functional brain abnormalities of German-speaking dyslexics who suffer from slow effortful reading but not from a reading accuracy problem. Similar to acquired cases of letter-by-letter reading, the developmental cases exhibited an abnormal strong effect of length (i.e., number of letters) on response time for words and pseudowords.<h4>Results</h4>Corresponding to lesions of left occipito-temporal (OT) regions in acquired cases, we found a dysfunction of this region in our developmental cases who failed to exhibit responsiveness of left OT regions to the length of words and pseudowords. This abnormality in the left OT cortex was accompanied by absent responsiveness to increased sublexical reading demands in phonological inferior frontal gyrus (IFG) regions. Interestingly, there was no abnormality in the left superior temporal cortex which--corresponding to the onological deficit explanation--is considered to be the prime locus of the reading difficulties of developmental dyslexia cases.<h4>Conclusions</h4>The present functional imaging results suggest that developmental dyslexia similar to acquired letter-by-letter reading is due to a primary dysfunction of left OT regions.
format	article
author	Fabio Richlan Denise Sturm Matthias Schurz Martin Kronbichler Gunther Ladurner Heinz Wimmer
author_facet	Fabio Richlan Denise Sturm Matthias Schurz Martin Kronbichler Gunther Ladurner Heinz Wimmer
author_sort	Fabio Richlan
title	A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
title_short	A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
title_full	A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
title_fullStr	A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
title_full_unstemmed	A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
title_sort	common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4e06621c79e146de9102f5028d4c6b66
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A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?

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