[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury

Objective: To investigate the effect of β-caryophyllene (BCP) on renal ischaemia–reperfusion injury (IRI)-induced renal dysfunction, as IRI causes renal functional alterations that might lead to permanent renal impairment and BCP (a natural bicyclic sesquiterpene and constituent of many essential oi...

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Autores principales:	Fayez Hammad, Shreesh Ojha, S. Azimullah, Loay Lubbad
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/4e073a9326234276bc60dfadfb3bbb03
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spelling	oai:doaj.org-article:4e073a9326234276bc60dfadfb3bbb032021-12-02T12:02:03Z[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury2090-598X10.1016/j.aju.2018.10.011https://doaj.org/article/4e073a9326234276bc60dfadfb3bbb032018-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X18301050https://doaj.org/toc/2090-598XObjective: To investigate the effect of β-caryophyllene (BCP) on renal ischaemia–reperfusion injury (IRI)-induced renal dysfunction, as IRI causes renal functional alterations that might lead to permanent renal impairment and BCP (a natural bicyclic sesquiterpene and constituent of many essential oils and spices) has been shown to exhibit anti-inflammatory, antioxidant, antispasmodic and chemopreventive activities in several organs. BCP is a USA Food and Drug Administration (FDA)-approved food additive and its effect on IRI has not been investigated. Methods: Wistar rats underwent left renal warm ischaemia for 40 min. The G-BCP group (n = 13) received oral BCP (50 mg/kg/day) dissolved in a vehicle starting 7 days before IRI and continued 7 days thereafter when the renal functions of both kidneys and the tissue level of some oxidative stress markers and pro-inflammatory cytokines were measured. The G-Vx group (n = 13) underwent the same protocol but received vehicle only. Results: IRI effected haemodynamic (renal blood flow and glomerular filtration rate) and tubular (urine volume, total and fractional urinary sodium excretion) parameters in the left ischaemic kidney in the G-Vx group. BCP did not affect any of these alterations in the ischaemic kidney (all P> 0.05). However, it attenuated the alterations in malondialdehyde (MDA) and glutathione (GSH) in the left ischaemic kidney in the G-BCP group compared to the G-Vx group, at a mean (SD) MDA level of 9.3 (2.1) vs 4.8 (1.0) μ mol/L (P = 0.047) and GSH level of 18.1 (2.5) vs 13.6 (1.7) mmoL/L, (P = 0.09). Conclusion: BCP appears to have no significant protective effect on the haemodynamic and tubular glomerular functions when measured 7 days after IRI, despite the attenuation in the alterations in some of the oxidative stress markers indicating a weak reno-protective effect of BCP in this condition.Fayez HammadShreesh OjhaS. AzimullahLoay LubbadTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss , Pp S28-S29 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Fayez Hammad Shreesh Ojha S. Azimullah Loay Lubbad [58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury
description	Objective: To investigate the effect of β-caryophyllene (BCP) on renal ischaemia–reperfusion injury (IRI)-induced renal dysfunction, as IRI causes renal functional alterations that might lead to permanent renal impairment and BCP (a natural bicyclic sesquiterpene and constituent of many essential oils and spices) has been shown to exhibit anti-inflammatory, antioxidant, antispasmodic and chemopreventive activities in several organs. BCP is a USA Food and Drug Administration (FDA)-approved food additive and its effect on IRI has not been investigated. Methods: Wistar rats underwent left renal warm ischaemia for 40 min. The G-BCP group (n = 13) received oral BCP (50 mg/kg/day) dissolved in a vehicle starting 7 days before IRI and continued 7 days thereafter when the renal functions of both kidneys and the tissue level of some oxidative stress markers and pro-inflammatory cytokines were measured. The G-Vx group (n = 13) underwent the same protocol but received vehicle only. Results: IRI effected haemodynamic (renal blood flow and glomerular filtration rate) and tubular (urine volume, total and fractional urinary sodium excretion) parameters in the left ischaemic kidney in the G-Vx group. BCP did not affect any of these alterations in the ischaemic kidney (all P> 0.05). However, it attenuated the alterations in malondialdehyde (MDA) and glutathione (GSH) in the left ischaemic kidney in the G-BCP group compared to the G-Vx group, at a mean (SD) MDA level of 9.3 (2.1) vs 4.8 (1.0) μ mol/L (P = 0.047) and GSH level of 18.1 (2.5) vs 13.6 (1.7) mmoL/L, (P = 0.09). Conclusion: BCP appears to have no significant protective effect on the haemodynamic and tubular glomerular functions when measured 7 days after IRI, despite the attenuation in the alterations in some of the oxidative stress markers indicating a weak reno-protective effect of BCP in this condition.
format	article
author	Fayez Hammad Shreesh Ojha S. Azimullah Loay Lubbad
author_facet	Fayez Hammad Shreesh Ojha S. Azimullah Loay Lubbad
author_sort	Fayez Hammad
title	[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury
title_short	[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury
title_full	[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury
title_fullStr	[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury
title_full_unstemmed	[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury
title_sort	[58] the effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/4e073a9326234276bc60dfadfb3bbb03
work_keys_str_mv	AT fayezhammad 58theeffectofbcaryophylleneonrenaldysfunctionfollowingischaemiareperfusioninjury AT shreeshojha 58theeffectofbcaryophylleneonrenaldysfunctionfollowingischaemiareperfusioninjury AT sazimullah 58theeffectofbcaryophylleneonrenaldysfunctionfollowingischaemiareperfusioninjury AT loaylubbad 58theeffectofbcaryophylleneonrenaldysfunctionfollowingischaemiareperfusioninjury
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[58] The effect of β-caryophyllene on renal dysfunction following ischaemia–reperfusion injury

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