Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia

Canine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chron...

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Autores principales:	Aničić Milan, Vučićević Ivana, Vasković Nikola, Radojičić Sonja, Juntes Polona, Nešić Slađan, Aleksić-Kovačević Sanja, Marinković Darko
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	brain canine distemper virus histopathology immunohistochemistry red fox Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/4e0a54b9d3374d19afdedc7f4308db48
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spelling	oai:doaj.org-article:4e0a54b9d3374d19afdedc7f4308db482021-11-17T21:27:53ZHistopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia1820-744810.2478/acve-2018-0035https://doaj.org/article/4e0a54b9d3374d19afdedc7f4308db482018-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2018-0035https://doaj.org/toc/1820-7448Canine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of routine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife.Aničić MilanVučićević IvanaVasković NikolaRadojičić SonjaJuntes PolonaNešić SlađanAleksić-Kovačević SanjaMarinković DarkoSciendoarticlebraincanine distemper virushistopathologyimmunohistochemistryred foxVeterinary medicineSF600-1100ENActa Veterinaria, Vol 68, Iss 4, Pp 434-444 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain canine distemper virus histopathology immunohistochemistry red fox Veterinary medicine SF600-1100
spellingShingle	brain canine distemper virus histopathology immunohistochemistry red fox Veterinary medicine SF600-1100 Aničić Milan Vučićević Ivana Vasković Nikola Radojičić Sonja Juntes Polona Nešić Slađan Aleksić-Kovačević Sanja Marinković Darko Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia
description	Canine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of routine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife.
format	article
author	Aničić Milan Vučićević Ivana Vasković Nikola Radojičić Sonja Juntes Polona Nešić Slađan Aleksić-Kovačević Sanja Marinković Darko
author_facet	Aničić Milan Vučićević Ivana Vasković Nikola Radojičić Sonja Juntes Polona Nešić Slađan Aleksić-Kovačević Sanja Marinković Darko
author_sort	Aničić Milan
title	Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia
title_short	Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia
title_full	Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia
title_fullStr	Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia
title_full_unstemmed	Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia
title_sort	histopathological characteristics and expression of cdv-np antigen in the brain of serologically positive spontaneously infected red foxes (vulpes vulpes) in western serbia
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/4e0a54b9d3374d19afdedc7f4308db48
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Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia

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