Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Abstract Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation. In this study, we investigated a hypothesis that inhibition of Cdc42 activity by CASIN, a small molecule Cdc42 Activity-Specific INhibitor, may down regulate platelet activation and thrombus formation. We investig...

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Autores principales: Xin Duan, Rehana Perveen, Akhila Dandamudi, Reheman Adili, James Johnson, Kevin Funk, Mark Berryman, Ashley Kuenzi Davis, Michael Holinstat, Yi Zheng, Huzoor Akbar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/4e0ab58442d54fbc9bafc38cdf9a72ae
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