The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and...

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Autores principales:	Evgenii Gusev, Liliya Solomatina, Yulia Zhuravleva, Alexey Sarapultsev
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cellular stress chronic low-grade inflammation chronic systemic inflammation classical inflammation end-stage renal disease cytokines Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4e12ed5c050d405ca18e84e93ac0d6c9
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spelling	oai:doaj.org-article:4e12ed5c050d405ca18e84e93ac0d6c92021-11-11T16:54:54ZThe Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation10.3390/ijms2221114531422-00671661-6596https://doaj.org/article/4e12ed5c050d405ca18e84e93ac0d6c92021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11453https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and dysfunctions of internal organs, skeletal muscles, and integumentary tissues. The common components of ESRD pathogenesis, regardless of the initial nosology, are (1) local (in the kidneys) and systemic chronic low-grade inflammation (ChLGI) as a risk factor for diabetic kidney disease and its progression to ESRD, (2) inflammation of the classical type characteristic of primary and secondary autoimmune glomerulonephritis and infectious recurrent pyelonephritis, as well as immune reactions in kidney allograft rejection, and (3) chronic systemic inflammation (ChSI), pathogenetically characterized by latent microcirculatory disorders and manifestations of paracoagulation. The development of ChSI is closely associated with programmed hemodialysis in ESRD, as well as with the systemic autoimmune process. Consideration of ESRD pathogenesis from the standpoint of the theory of general pathological processes opens up the scope not only for particular but also for universal approaches to conducting pathogenetic therapies and diagnosing and predicting systemic complications in severe nephropathies.Evgenii GusevLiliya SolomatinaYulia ZhuravlevaAlexey SarapultsevMDPI AGarticlecellular stresschronic low-grade inflammationchronic systemic inflammationclassical inflammationend-stage renal diseasecytokinesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11453, p 11453 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cellular stress chronic low-grade inflammation chronic systemic inflammation classical inflammation end-stage renal disease cytokines Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cellular stress chronic low-grade inflammation chronic systemic inflammation classical inflammation end-stage renal disease cytokines Biology (General) QH301-705.5 Chemistry QD1-999 Evgenii Gusev Liliya Solomatina Yulia Zhuravleva Alexey Sarapultsev The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation
description	Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and dysfunctions of internal organs, skeletal muscles, and integumentary tissues. The common components of ESRD pathogenesis, regardless of the initial nosology, are (1) local (in the kidneys) and systemic chronic low-grade inflammation (ChLGI) as a risk factor for diabetic kidney disease and its progression to ESRD, (2) inflammation of the classical type characteristic of primary and secondary autoimmune glomerulonephritis and infectious recurrent pyelonephritis, as well as immune reactions in kidney allograft rejection, and (3) chronic systemic inflammation (ChSI), pathogenetically characterized by latent microcirculatory disorders and manifestations of paracoagulation. The development of ChSI is closely associated with programmed hemodialysis in ESRD, as well as with the systemic autoimmune process. Consideration of ESRD pathogenesis from the standpoint of the theory of general pathological processes opens up the scope not only for particular but also for universal approaches to conducting pathogenetic therapies and diagnosing and predicting systemic complications in severe nephropathies.
format	article
author	Evgenii Gusev Liliya Solomatina Yulia Zhuravleva Alexey Sarapultsev
author_facet	Evgenii Gusev Liliya Solomatina Yulia Zhuravleva Alexey Sarapultsev
author_sort	Evgenii Gusev
title	The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation
title_short	The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation
title_full	The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation
title_fullStr	The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation
title_full_unstemmed	The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation
title_sort	pathogenesis of end-stage renal disease from the standpoint of the theory of general pathological processes of inflammation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e12ed5c050d405ca18e84e93ac0d6c9
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The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

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