Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest

Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by Leishmania spp., the loss of white pulp accompanies a severe clinical presentation. Hamster model reproduces aspects of human VL progression. In th...

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Autores principales: Caroline Vilas Boas de Melo, Felipe Guimarães Torres, Micely D’El-Rei Hermida, Jonathan L. M. Fontes, Bianca Ramos Mesquita, Reginaldo Brito, Pablo Ivan P. Ramos, Gabriel R. Fernandes, Luiz Antônio Rodrigues Freitas, Ricardo Khouri, Carlos Henrique Nery Costa, Washington L. C. dos-Santos
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
visceral leishmanaisis
white pulp remodeling
spleen disorganization
transcriptomic (RNA-Seq)
spleen pathology
hamster
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/4e144ad9b0484102a3c0edf2d8144b85
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https://doaj.org/article/4e144ad9b0484102a3c0edf2d8144b85

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