A mechanochemical model of cell reorientation on substrates under cyclic stretch.

We report a theoretical study on the cyclic stretch-induced reorientation of spindle-shaped cells. Specifically, by taking into account the evolution of sub-cellular structures like the contractile stress fibers and adhesive receptor-ligand clusters, we develop a mechanochemical model to describe th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jin Qian, Haipei Liu, Yuan Lin, Weiqiu Chen, Huajian Gao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e16f72a626742dca82067d4da8ea9ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e16f72a626742dca82067d4da8ea9ff
record_format	dspace
spelling	oai:doaj.org-article:4e16f72a626742dca82067d4da8ea9ff2021-11-18T07:42:43ZA mechanochemical model of cell reorientation on substrates under cyclic stretch.1932-620310.1371/journal.pone.0065864https://doaj.org/article/4e16f72a626742dca82067d4da8ea9ff2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762444/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203We report a theoretical study on the cyclic stretch-induced reorientation of spindle-shaped cells. Specifically, by taking into account the evolution of sub-cellular structures like the contractile stress fibers and adhesive receptor-ligand clusters, we develop a mechanochemical model to describe the dynamics of cell realignment in response to cyclically stretched substrates. Our main hypothesis is that cells tend to orient in the direction where the formation of stress fibers is energetically most favorable. We show that, when subjected to cyclic stretch, the final alignment of cells reflects the competition between the elevated force within stress fibers that accelerates their disassembly and the disruption of cell-substrate adhesion as well, and an effectively increased substrate rigidity that promotes more stable focal adhesions. Our model predictions are consistent with various observations like the substrate rigidity dependent formation of stable adhesions and the stretching frequency, as well as stretching amplitude, dependence of cell realignment. This theory also provides a simple explanation on the regulation of protein Rho in the formation of stretch-induced stress fibers in cells.Jin QianHaipei LiuYuan LinWeiqiu ChenHuajian GaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65864 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin Qian Haipei Liu Yuan Lin Weiqiu Chen Huajian Gao A mechanochemical model of cell reorientation on substrates under cyclic stretch.
description	We report a theoretical study on the cyclic stretch-induced reorientation of spindle-shaped cells. Specifically, by taking into account the evolution of sub-cellular structures like the contractile stress fibers and adhesive receptor-ligand clusters, we develop a mechanochemical model to describe the dynamics of cell realignment in response to cyclically stretched substrates. Our main hypothesis is that cells tend to orient in the direction where the formation of stress fibers is energetically most favorable. We show that, when subjected to cyclic stretch, the final alignment of cells reflects the competition between the elevated force within stress fibers that accelerates their disassembly and the disruption of cell-substrate adhesion as well, and an effectively increased substrate rigidity that promotes more stable focal adhesions. Our model predictions are consistent with various observations like the substrate rigidity dependent formation of stable adhesions and the stretching frequency, as well as stretching amplitude, dependence of cell realignment. This theory also provides a simple explanation on the regulation of protein Rho in the formation of stretch-induced stress fibers in cells.
format	article
author	Jin Qian Haipei Liu Yuan Lin Weiqiu Chen Huajian Gao
author_facet	Jin Qian Haipei Liu Yuan Lin Weiqiu Chen Huajian Gao
author_sort	Jin Qian
title	A mechanochemical model of cell reorientation on substrates under cyclic stretch.
title_short	A mechanochemical model of cell reorientation on substrates under cyclic stretch.
title_full	A mechanochemical model of cell reorientation on substrates under cyclic stretch.
title_fullStr	A mechanochemical model of cell reorientation on substrates under cyclic stretch.
title_full_unstemmed	A mechanochemical model of cell reorientation on substrates under cyclic stretch.
title_sort	mechanochemical model of cell reorientation on substrates under cyclic stretch.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4e16f72a626742dca82067d4da8ea9ff
work_keys_str_mv	AT jinqian amechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT haipeiliu amechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT yuanlin amechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT weiqiuchen amechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT huajiangao amechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT jinqian mechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT haipeiliu mechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT yuanlin mechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT weiqiuchen mechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch AT huajiangao mechanochemicalmodelofcellreorientationonsubstratesundercyclicstretch
_version_	1718423096134729728

A mechanochemical model of cell reorientation on substrates under cyclic stretch.

Ejemplares similares