Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia

Abstract The elevated level of D-dimer and its relationship with poor outcomes in SARS-COV-2 pneumonia patients have been demonstrated. In addition to a hypercoagulable state, D-dimer is also a biomarker of inflammation. We investigated the relationship between D-dimer level and chest computed tomog...

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Autores principales:	Lan Wang, Ling Yang, Lang Bai, Zhixin Huang, Yong Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e1f2bdae5a34568b31494c15ae603b6
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spelling	oai:doaj.org-article:4e1f2bdae5a34568b31494c15ae603b62021-12-02T17:50:41ZAssociation between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia10.1038/s41598-021-91150-12045-2322https://doaj.org/article/4e1f2bdae5a34568b31494c15ae603b62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91150-1https://doaj.org/toc/2045-2322Abstract The elevated level of D-dimer and its relationship with poor outcomes in SARS-COV-2 pneumonia patients have been demonstrated. In addition to a hypercoagulable state, D-dimer is also a biomarker of inflammation. We investigated the relationship between D-dimer level and chest computed tomography (CT) severity score, which could reflect the severity of inflammation in SARS-COV-2 pneumonia patients. We retrospectively enrolled 86 consecutive SARS-COV-2 pneumonia patients. CT severity scores were computed to quantify the overall lung involvement. The D-dimer level among CT score tertiles and the association of the D-dimer level with CT score were analyzed. Our results showed that the median D-dimer level was 0.70 mg/L (IQR 0.35–1.76). 42 patients (48.8%) had D-dimer levels above the median level. The D-dimer levels were significantly different across CT score tertiles (0.37 mg/l [IQR 0.31–0.87], 0.66 mg/l [IQR 0.39–1.43], 1.83 mg/l [IQR 0.85–4.41], P < 0.001). The natural logarithm of the D-dimer level was significantly associated with the CT score (rs = 0.586, P < 0.001). In conclusion, the D-dimer level may be associated with the severity of inflammation of SARS-COV-2 pneumonia prior to coagulopathy/thrombosis. This could be an additional explanation for the mechanism of the relationship between elevated D-dimer level and higher mortality.Lan WangLing YangLang BaiZhixin HuangYong PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lan Wang Ling Yang Lang Bai Zhixin Huang Yong Peng Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia
description	Abstract The elevated level of D-dimer and its relationship with poor outcomes in SARS-COV-2 pneumonia patients have been demonstrated. In addition to a hypercoagulable state, D-dimer is also a biomarker of inflammation. We investigated the relationship between D-dimer level and chest computed tomography (CT) severity score, which could reflect the severity of inflammation in SARS-COV-2 pneumonia patients. We retrospectively enrolled 86 consecutive SARS-COV-2 pneumonia patients. CT severity scores were computed to quantify the overall lung involvement. The D-dimer level among CT score tertiles and the association of the D-dimer level with CT score were analyzed. Our results showed that the median D-dimer level was 0.70 mg/L (IQR 0.35–1.76). 42 patients (48.8%) had D-dimer levels above the median level. The D-dimer levels were significantly different across CT score tertiles (0.37 mg/l [IQR 0.31–0.87], 0.66 mg/l [IQR 0.39–1.43], 1.83 mg/l [IQR 0.85–4.41], P < 0.001). The natural logarithm of the D-dimer level was significantly associated with the CT score (rs = 0.586, P < 0.001). In conclusion, the D-dimer level may be associated with the severity of inflammation of SARS-COV-2 pneumonia prior to coagulopathy/thrombosis. This could be an additional explanation for the mechanism of the relationship between elevated D-dimer level and higher mortality.
format	article
author	Lan Wang Ling Yang Lang Bai Zhixin Huang Yong Peng
author_facet	Lan Wang Ling Yang Lang Bai Zhixin Huang Yong Peng
author_sort	Lan Wang
title	Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia
title_short	Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia
title_full	Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia
title_fullStr	Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia
title_full_unstemmed	Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia
title_sort	association between d-dimer level and chest ct severity score in patients with sars-cov-2 pneumonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e1f2bdae5a34568b31494c15ae603b6
work_keys_str_mv	AT lanwang associationbetweenddimerlevelandchestctseverityscoreinpatientswithsarscov2pneumonia AT lingyang associationbetweenddimerlevelandchestctseverityscoreinpatientswithsarscov2pneumonia AT langbai associationbetweenddimerlevelandchestctseverityscoreinpatientswithsarscov2pneumonia AT zhixinhuang associationbetweenddimerlevelandchestctseverityscoreinpatientswithsarscov2pneumonia AT yongpeng associationbetweenddimerlevelandchestctseverityscoreinpatientswithsarscov2pneumonia
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Association between D-dimer level and chest CT severity score in patients with SARS-COV-2 pneumonia

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