Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves

Abstract Adipose tissue represents not only an important energy storage tissue but also a major endocrine organ within the body, influencing many biochemical systems including metabolic status, immune function and energy homeostasis. The objective of this study was to evaluate the effect of an enhan...

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Autores principales:	Kate Keogh, Alan K. Kelly, David A. Kenny
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e20abc343fd4a5996582680277a6834
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spelling	oai:doaj.org-article:4e20abc343fd4a5996582680277a68342021-12-02T14:49:25ZEffect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves10.1038/s41598-021-89252-x2045-2322https://doaj.org/article/4e20abc343fd4a5996582680277a68342021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89252-xhttps://doaj.org/toc/2045-2322Abstract Adipose tissue represents not only an important energy storage tissue but also a major endocrine organ within the body, influencing many biochemical systems including metabolic status, immune function and energy homeostasis. The objective of this study was to evaluate the effect of an enhanced dietary intake during the early calfhood period on the transcriptome of visceral adipose tissue. Artificially reared Angus × Holstein–Friesian heifer calves were offered either a high (HI, n = 15) or moderate (MOD, n = 15) plane of nutrition from 3 to 21 weeks of life. At 21 weeks of age all calves were euthanized, visceral adipose harvested and samples subsequently subjected to mRNA sequencing. Plane of nutrition resulted in the differential expression of 1214 genes within visceral adipose tissue (adj. p < 0.05; fold change > 1.5). Differentially expressed genes were involved in processes related to metabolism and energy production. Biochemical pathways including Sirtuin signalling (adj. p < 0.0001) and the adipogenesis pathways (adj. p = 0.009) were also significantly enriched, indicating greater metabolic processing and adipogenesis in the calves on the high plane of nutrition. Results from this study identify novel genes regulating the molecular response of visceral adipose tissue to an improved plane of nutrition during early calfhood.Kate KeoghAlan K. KellyDavid A. KennyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kate Keogh Alan K. Kelly David A. Kenny Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves
description	Abstract Adipose tissue represents not only an important energy storage tissue but also a major endocrine organ within the body, influencing many biochemical systems including metabolic status, immune function and energy homeostasis. The objective of this study was to evaluate the effect of an enhanced dietary intake during the early calfhood period on the transcriptome of visceral adipose tissue. Artificially reared Angus × Holstein–Friesian heifer calves were offered either a high (HI, n = 15) or moderate (MOD, n = 15) plane of nutrition from 3 to 21 weeks of life. At 21 weeks of age all calves were euthanized, visceral adipose harvested and samples subsequently subjected to mRNA sequencing. Plane of nutrition resulted in the differential expression of 1214 genes within visceral adipose tissue (adj. p < 0.05; fold change > 1.5). Differentially expressed genes were involved in processes related to metabolism and energy production. Biochemical pathways including Sirtuin signalling (adj. p < 0.0001) and the adipogenesis pathways (adj. p = 0.009) were also significantly enriched, indicating greater metabolic processing and adipogenesis in the calves on the high plane of nutrition. Results from this study identify novel genes regulating the molecular response of visceral adipose tissue to an improved plane of nutrition during early calfhood.
format	article
author	Kate Keogh Alan K. Kelly David A. Kenny
author_facet	Kate Keogh Alan K. Kelly David A. Kenny
author_sort	Kate Keogh
title	Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves
title_short	Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves
title_full	Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves
title_fullStr	Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves
title_full_unstemmed	Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves
title_sort	effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in angus heifer calves
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e20abc343fd4a5996582680277a6834
work_keys_str_mv	AT katekeogh effectofplaneofnutritioninearlylifeonthetranscriptomeofvisceraladiposetissueinangusheifercalves AT alankkelly effectofplaneofnutritioninearlylifeonthetranscriptomeofvisceraladiposetissueinangusheifercalves AT davidakenny effectofplaneofnutritioninearlylifeonthetranscriptomeofvisceraladiposetissueinangusheifercalves
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Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves

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