Clinical utility of the risperidone formulations in the management of schizophrenia

Vishal Madaan1, Durga P Bestha2, Venkata Kolli2, Saurabh Jauhari2, Roger C Burket1 1University of Virginia Health System, Charlottesville, VA, USA; 2Creighton University Medical Center, Omaha, NE, USA Abstract: Risperidone is one of the early second-generation antipsychotics that came into the limel...

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Autores principales:	Madaan V, Bestha DP, Kolli VB, Jauhari S, Burket RC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4e22fb417ecc4272945dff6c78e223b5
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spelling	oai:doaj.org-article:4e22fb417ecc4272945dff6c78e223b52021-12-02T01:38:51ZClinical utility of the risperidone formulations in the management of schizophrenia1176-63281178-2021https://doaj.org/article/4e22fb417ecc4272945dff6c78e223b52011-10-01T00:00:00Zhttp://www.dovepress.com/clinical-utility-of-the-risperidone-formulations-in-the-management-of--a8488https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Vishal Madaan1, Durga P Bestha2, Venkata Kolli2, Saurabh Jauhari2, Roger C Burket1 1University of Virginia Health System, Charlottesville, VA, USA; 2Creighton University Medical Center, Omaha, NE, USA Abstract: Risperidone is one of the early second-generation antipsychotics that came into the limelight in the early 1990s. Both the oral and long-acting injectable formulations have been subject to numerous studies to assess their safety, efficacy, and tolerability. Risperidone is currently one of the most widely prescribed antipsychotic medications, used for both acute and long-term maintenance in schizophrenia. Risperidone has better efficacy in the treatment of psychotic symptoms than placebo and possibly many first-generation antipsychotics. Risperidone fares better than placebo and first-generation antipsychotics in the treatment of negative symptoms. Risperidone&#39;s long acting injectable preparation has been well tolerated and is often useful in patients with medication nonadherence. Risperidone has a higher risk of hyperprolactinemia comparable to first-generation antipsychotics (FGAs) but fares better than many second-generation antipsychotics with regards to metabolic side effects. In this article, we briefly review the recent literature exploring the role of risperidone formulations in schizophrenia, discuss clinical usage, and highlight the controversies and challenges associated with its use. Keywords: risperidone, schizophrenia, formulation, antipsychotic, side effectsMadaan VBestha DPKolli VBJauhari SBurket RCDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 611-620 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Madaan V Bestha DP Kolli VB Jauhari S Burket RC Clinical utility of the risperidone formulations in the management of schizophrenia
description	Vishal Madaan1, Durga P Bestha2, Venkata Kolli2, Saurabh Jauhari2, Roger C Burket1 1University of Virginia Health System, Charlottesville, VA, USA; 2Creighton University Medical Center, Omaha, NE, USA Abstract: Risperidone is one of the early second-generation antipsychotics that came into the limelight in the early 1990s. Both the oral and long-acting injectable formulations have been subject to numerous studies to assess their safety, efficacy, and tolerability. Risperidone is currently one of the most widely prescribed antipsychotic medications, used for both acute and long-term maintenance in schizophrenia. Risperidone has better efficacy in the treatment of psychotic symptoms than placebo and possibly many first-generation antipsychotics. Risperidone fares better than placebo and first-generation antipsychotics in the treatment of negative symptoms. Risperidone&#39;s long acting injectable preparation has been well tolerated and is often useful in patients with medication nonadherence. Risperidone has a higher risk of hyperprolactinemia comparable to first-generation antipsychotics (FGAs) but fares better than many second-generation antipsychotics with regards to metabolic side effects. In this article, we briefly review the recent literature exploring the role of risperidone formulations in schizophrenia, discuss clinical usage, and highlight the controversies and challenges associated with its use. Keywords: risperidone, schizophrenia, formulation, antipsychotic, side effects
format	article
author	Madaan V Bestha DP Kolli VB Jauhari S Burket RC
author_facet	Madaan V Bestha DP Kolli VB Jauhari S Burket RC
author_sort	Madaan V
title	Clinical utility of the risperidone formulations in the management of schizophrenia
title_short	Clinical utility of the risperidone formulations in the management of schizophrenia
title_full	Clinical utility of the risperidone formulations in the management of schizophrenia
title_fullStr	Clinical utility of the risperidone formulations in the management of schizophrenia
title_full_unstemmed	Clinical utility of the risperidone formulations in the management of schizophrenia
title_sort	clinical utility of the risperidone formulations in the management of schizophrenia
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/4e22fb417ecc4272945dff6c78e223b5
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Clinical utility of the risperidone formulations in the management of schizophrenia

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