Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications

Background: Leukemia is a varied group of hematological malignancies due to uncontrolled proliferation of blast cells. Among childhood leukemias, acute lymphoblastic leukemia (ALL) comprise 70%–80% of all childhood leukemias in India. The current study aims to report the various prognostic markers o...

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Autores principales:	Shweta Jha, Dinesh Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	acute lymphoblastic leukemia cytogenetics flow cytometry immunophenotyping Human anatomy QM1-695
Acceso en línea:	https://doaj.org/article/4e27a4316c4448ee9c91972d5fcc5285
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spelling	oai:doaj.org-article:4e27a4316c4448ee9c91972d5fcc52852021-11-12T10:25:52ZAcute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications2277-40252321-278010.4103/NJCA.NJCA_49_21https://doaj.org/article/4e27a4316c4448ee9c91972d5fcc52852021-01-01T00:00:00Zhttp://www.njca.info/article.asp?issn=2277-4025;year=2021;volume=10;issue=4;spage=214;epage=219;aulast=Jhahttps://doaj.org/toc/2277-4025https://doaj.org/toc/2321-2780Background: Leukemia is a varied group of hematological malignancies due to uncontrolled proliferation of blast cells. Among childhood leukemias, acute lymphoblastic leukemia (ALL) comprise 70%–80% of all childhood leukemias in India. The current study aims to report the various prognostic markers of disease severity. Methodology: Bone marrow and peripheral blood samples from 20 patients of ALL were subjected to cytogenetic and flow cytometric analysis after recording clinical history and laboratory findings. Patients were classified according to immunophenotyping markers.: For risk stratification, patients were divided into two subgroups B ALL and T ALL. The age group of majority of patients was 1–9 years (90%) with 5% each belonging to <1 and >9 years. Male: female ratio was 1.1:1. Results: Hepatosplenomegaly, lymphadenopathy, and mediastinal involvement was found in 45%, 40%, and 5% of patients, respectively. Hemoglobin levels <5 g/dl and >5 g/dl were seen in 50% of patients in each range. White blood cell counts >50,000 were seen in 3 (15%) of patients. Cytogenetic analysis revealed hypodiploid karyotype for majority (64%) of cases, normal karyotype in 28% and hyperdiploidy in rest (7%). Structural aberrations like t (21;4), del (5p), dic (5) were found all in B ALL subgroup. Patients were stratified into high and standard risk groups based on good and prognostic factors. Conclusions: This study reinforces the significance of immunophenotyping cytogenetics, clinical presentation as a prognostic tool, and their significance in risk stratification.Shweta JhaDinesh KumarWolters Kluwer Medknow Publicationsarticleacute lymphoblastic leukemiacytogeneticsflow cytometryimmunophenotypingHuman anatomyQM1-695ENNational Journal of Clinical Anatomy, Vol 10, Iss 4, Pp 214-219 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute lymphoblastic leukemia cytogenetics flow cytometry immunophenotyping Human anatomy QM1-695
spellingShingle	acute lymphoblastic leukemia cytogenetics flow cytometry immunophenotyping Human anatomy QM1-695 Shweta Jha Dinesh Kumar Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications
description	Background: Leukemia is a varied group of hematological malignancies due to uncontrolled proliferation of blast cells. Among childhood leukemias, acute lymphoblastic leukemia (ALL) comprise 70%–80% of all childhood leukemias in India. The current study aims to report the various prognostic markers of disease severity. Methodology: Bone marrow and peripheral blood samples from 20 patients of ALL were subjected to cytogenetic and flow cytometric analysis after recording clinical history and laboratory findings. Patients were classified according to immunophenotyping markers.: For risk stratification, patients were divided into two subgroups B ALL and T ALL. The age group of majority of patients was 1–9 years (90%) with 5% each belonging to <1 and >9 years. Male: female ratio was 1.1:1. Results: Hepatosplenomegaly, lymphadenopathy, and mediastinal involvement was found in 45%, 40%, and 5% of patients, respectively. Hemoglobin levels <5 g/dl and >5 g/dl were seen in 50% of patients in each range. White blood cell counts >50,000 were seen in 3 (15%) of patients. Cytogenetic analysis revealed hypodiploid karyotype for majority (64%) of cases, normal karyotype in 28% and hyperdiploidy in rest (7%). Structural aberrations like t (21;4), del (5p), dic (5) were found all in B ALL subgroup. Patients were stratified into high and standard risk groups based on good and prognostic factors. Conclusions: This study reinforces the significance of immunophenotyping cytogenetics, clinical presentation as a prognostic tool, and their significance in risk stratification.
format	article
author	Shweta Jha Dinesh Kumar
author_facet	Shweta Jha Dinesh Kumar
author_sort	Shweta Jha
title	Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications
title_short	Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications
title_full	Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications
title_fullStr	Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications
title_full_unstemmed	Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications
title_sort	acute lymphoblastic leukemia in indian children at a tertiary care center: a multiparametric study with prognostic implications
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/4e27a4316c4448ee9c91972d5fcc5285
work_keys_str_mv	AT shwetajha acutelymphoblasticleukemiainindianchildrenatatertiarycarecenteramultiparametricstudywithprognosticimplications AT dineshkumar acutelymphoblasticleukemiainindianchildrenatatertiarycarecenteramultiparametricstudywithprognosticimplications
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Acute lymphoblastic leukemia in Indian children at a tertiary care center: A multiparametric study with prognostic implications

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