Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia

The one-carbon metabolism pathway is a suitable candidate for studying the genetic and epigenetic factors contributing to metabolic abnormalities in patients with schizophrenia. We recruited 232 patients with schizophrenia and analyzed their serum folate, vitamin B12, and homocysteine levels and met...

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Autores principales:	Chun-Hsin Chen, Po-Yu Chen, Cynthia Yi-An Chen, Chih-Chiang Chiu, Mong-Liang Lu, Ming-Chyi Huang, Yen-Kuang Lin, Yi-Hua Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	folate methylenetetrahydrofolate reductase metabolic parameters one-carbon metabolism schizophrenia Medicine R
Acceso en línea:	https://doaj.org/article/4e28f97081154f548c2d2d848d492524
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spelling	oai:doaj.org-article:4e28f97081154f548c2d2d848d4925242021-11-11T16:28:26ZAssociations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia10.3390/ijerph1821113331660-46011661-7827https://doaj.org/article/4e28f97081154f548c2d2d848d4925242021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11333https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601The one-carbon metabolism pathway is a suitable candidate for studying the genetic and epigenetic factors contributing to metabolic abnormalities in patients with schizophrenia. We recruited 232 patients with schizophrenia and analyzed their serum folate, vitamin B12, and homocysteine levels and metabolic parameters to investigate the associations of genetic variants of methylenetetrahydrofolate reductase (<i>MTHFR</i>) and folate levels with metabolic parameters. <i>MTHFR</i> C677T and <i>MTHFR</i> A1298C were genotyped. Results showed that <i>MTHFR</i> 677T allele carriers had lower levels of total cholesterol and low-density lipoprotein cholesterol than those with the 677CC genotype. Metabolic parameters did not differ between <i>MTHFR</i> 1298C and 1298AA carriers. Patients with a low folate level had a lower high-density lipoprotein cholesterol level than those with a normal folate level, but the effect disappeared after adjustment for age, sex, and types of antipsychotics used. We found significant interactions between <i>MTHFR</i> A1298C and the folate level status (low vs. normal) in terms of body mass index and waist circumference. In conclusion, genetic variants in one-carbon metabolism might play a role in antipsychotic-induced metabolic abnormalities. Prospective studies on drug-naïve, first-episode patients with schizophrenia are warranted to identify key regions of DNA methylation changes accounting for antipsychotic-induced metabolic abnormalities.Chun-Hsin ChenPo-Yu ChenCynthia Yi-An ChenChih-Chiang ChiuMong-Liang LuMing-Chyi HuangYen-Kuang LinYi-Hua ChenMDPI AGarticlefolatemethylenetetrahydrofolate reductasemetabolic parametersone-carbon metabolismschizophreniaMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11333, p 11333 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	folate methylenetetrahydrofolate reductase metabolic parameters one-carbon metabolism schizophrenia Medicine R
spellingShingle	folate methylenetetrahydrofolate reductase metabolic parameters one-carbon metabolism schizophrenia Medicine R Chun-Hsin Chen Po-Yu Chen Cynthia Yi-An Chen Chih-Chiang Chiu Mong-Liang Lu Ming-Chyi Huang Yen-Kuang Lin Yi-Hua Chen Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
description	The one-carbon metabolism pathway is a suitable candidate for studying the genetic and epigenetic factors contributing to metabolic abnormalities in patients with schizophrenia. We recruited 232 patients with schizophrenia and analyzed their serum folate, vitamin B12, and homocysteine levels and metabolic parameters to investigate the associations of genetic variants of methylenetetrahydrofolate reductase (<i>MTHFR</i>) and folate levels with metabolic parameters. <i>MTHFR</i> C677T and <i>MTHFR</i> A1298C were genotyped. Results showed that <i>MTHFR</i> 677T allele carriers had lower levels of total cholesterol and low-density lipoprotein cholesterol than those with the 677CC genotype. Metabolic parameters did not differ between <i>MTHFR</i> 1298C and 1298AA carriers. Patients with a low folate level had a lower high-density lipoprotein cholesterol level than those with a normal folate level, but the effect disappeared after adjustment for age, sex, and types of antipsychotics used. We found significant interactions between <i>MTHFR</i> A1298C and the folate level status (low vs. normal) in terms of body mass index and waist circumference. In conclusion, genetic variants in one-carbon metabolism might play a role in antipsychotic-induced metabolic abnormalities. Prospective studies on drug-naïve, first-episode patients with schizophrenia are warranted to identify key regions of DNA methylation changes accounting for antipsychotic-induced metabolic abnormalities.
format	article
author	Chun-Hsin Chen Po-Yu Chen Cynthia Yi-An Chen Chih-Chiang Chiu Mong-Liang Lu Ming-Chyi Huang Yen-Kuang Lin Yi-Hua Chen
author_facet	Chun-Hsin Chen Po-Yu Chen Cynthia Yi-An Chen Chih-Chiang Chiu Mong-Liang Lu Ming-Chyi Huang Yen-Kuang Lin Yi-Hua Chen
author_sort	Chun-Hsin Chen
title	Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
title_short	Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
title_full	Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
title_fullStr	Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
title_full_unstemmed	Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
title_sort	associations of genetic variants of methylenetetrahydrofolate reductase and serum folate levels with metabolic parameters in patients with schizophrenia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e28f97081154f548c2d2d848d492524
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Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia

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